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SU-5402 - ≥98%, high purity , CAS No.215543-92-3

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S276590
Grouped product items
SKU Size
Availability
 Price Qty
S276590-5mg
5mg
4
$72.90
S276590-10mg
10mg
3
$112.90
S276590-25mg
25mg
2
$254.90
S276590-50mg
50mg
1
$340.90
S276590-100mg
100mg
1
$543.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, selective VEGFR and FGFR inhibitor

View related series
FGFR (112) PDGFR (109) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) VEGFR (187)

Basic Description

Synonyms HY-10407G | BCPP000060 | SCHEMBL177917 | SU 5402 | su5402 | SU-5402 | (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;SU5402 | A19413 | 3-{4-methyl-2-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Potent, selective VEGFR and FGFR inhibitor (IC 50 values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo. Also available as a solid (
Storage Temp Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Describtion:

SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass Indolines
Intermediate Tree Nodes Not available
Direct Parent Indolines
Alternative Parents Substituted pyrroles  Benzenoids  Heteroaromatic compounds  Secondary carboxylic acid amides  Lactams  Monocarboxylic acids and derivatives  Carboxylic acids  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Dihydroindole - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Secondary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
External Descriptors Not available

Associated Targets(Human)

KDR Tclin Vascular endothelial growth factor receptor 2 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FLT1 Tclin Vascular endothelial growth factor receptor 1 (6262 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MST1R Tchem Macrophage-stimulating protein receptor (2327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MET Tclin Hepatocyte growth factor receptor (10718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EPHB2 Tchem Ephrin type-B receptor 2 (1899 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDGFRA Tclin Platelet-derived growth factor receptor alpha (5682 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EPHA2 Tclin Ephrin type-A receptor 2 (3499 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RET Tclin Tyrosine-protein kinase receptor RET (6732 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504763525
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504763525
IUPAC Name 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
INCHI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChIKey JNDVEAXZWJIOKB-JYRVWZFOSA-N
Smiles CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
Isomeric SMILES CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O
WGK Germany 3
Alternate CAS 215543-92-3
MeSH Entry Terms 3-((3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene)-2-inolinone;SU 5402;Su-5402;SU5402
Molecular Weight 296.32

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
G23181169 Certificate of Analysis May 16, 2024 S276590
G23181295 Certificate of Analysis May 16, 2024 S276590
G23181174 Certificate of Analysis May 16, 2024 S276590
G23181170 Certificate of Analysis May 16, 2024 S276590
G23181281 Certificate of Analysis May 16, 2024 S276590
G23181303 Certificate of Analysis May 10, 2024 S276590
G23181286 Certificate of Analysis May 10, 2024 S276590
G23181171 Certificate of Analysis May 10, 2024 S276590
F23061993 Certificate of Analysis May 10, 2024 S276590
F23061932 Certificate of Analysis May 10, 2024 S276590

Chemical and Physical Properties

Solubility Supplied in DMSO (10 mM)
Sensitivity air and light sensitive
Molecular Weight 296.320 g/mol
XLogP3 1.800
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 4
Exact Mass 296.116 Da
Monoisotopic Mass 296.116 Da
Topological Polar Surface Area 82.200 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 488.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Alternative Products

  1. SU-5402 (DMSO solution)
    SU-5402 (DMSO solution)
    • 10mM in DMSO

    Starting at $241.90

Solution Calculators

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