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Streptozocin - Moligand™, ≥75%, α-anomer basis, high purity , CAS No.18883-66-4

COA

Grade & Purity:

Moligand™

≥75%
α-anomer basis

Cas Number: 18883-66-4
Molecular Weight: 265.22
Beilstein Registry Number: 2060675
EC Number: 242-646-8
MDL number: MFCD00006607
PubChem CID: 29327

In stock

Item Number

S766968

Grouped product items
SKU	Size	Availability	Price
S766968-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$26.90
S766968-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
S766968-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$269.90
S766968-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90
S766968-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,999.90

Selective pancreatic β-cell toxin

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Basic Description

Synonyms	N-(Methylnitrosocarbamoyl)-α-D-glucosamine \| Streptozotocin \| 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose \| STZ \| NSC-85998 \| U-9889
Specifications & Purity	Moligand™, ≥75%, α-anomer basis
Biochemical and Physiological Mechanisms	An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroend
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells. An NO donor and DNA methylating agent; Streptozotocin is used in medicine as a drug against certain cancers of the Langerhans Islets. It is cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter; Streptozocin is used to induce Type 1 diabetes for medical research.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Carbohydrates and carbohydrate conjugates
      - Level5 Monosaccharides
        Level6 Hexoses

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes	Monosaccharides
Direct Parent	Hexoses
Alternative Parents	N-methylnitrosoureas Oxanes Semicarbazides Nitrosamides Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Hexose monosaccharide - N-methylnitrosourea - Nitrosourea - Oxane - Nitrosamide - Semicarbazide - Organic n-nitroso compound - Hemiacetal - Carbonic acid derivative - Secondary alcohol - Organic nitroso compound - Oxacycle - Polyol - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Carbonyl group - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
External Descriptors	N-nitrosoureas - N-acylglucosamine
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
INCHI	InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChIKey	ZSJLQEPLLKMAKR-GKHCUFPYSA-N
Smiles	CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Isomeric SMILES	CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
WGK Germany	3
RTECS	LZ5775000
UN Number	3077
Packing Group	III
Molecular Weight	265.22
Beilstein	2060675

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
E2509012	Certificate of Analysis	Apr 23, 2025	S766968
D2516578	Certificate of Analysis	Apr 23, 2025	S766968
D2516579	Certificate of Analysis	Apr 23, 2025	S766968

Chemical and Physical Properties

Solubility	Soluble in water (≥53 mg/ml), ethanol ( ≥3 mg/ml), and DMSO (≥53 mg/ml).
Sensitivity	Moisture sensitive；Light sensitive
Melt Point(°C)	115°C
Molecular Weight	265.220 g/mol
XLogP3	-1.400
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	265.091 Da
Monoisotopic Mass	265.091 Da
Topological Polar Surface Area	152.000 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	315.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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