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STL1267 - 99%, high purity , CAS No.1429024-58-7

COA

Grade & Purity:

≥99%

Cas Number: 1429024-58-7
Molecular Weight: 322.75

In stock

Item Number

S648879

Grouped product items
SKU	Size	Availability	Price
S648879-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
S648879-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$170.90
S648879-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
S648879-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90
S648879-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$920.90

View related series

Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) REV-ERB (7) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 In Vitro STL1267 (5 µM; 24 h) decreases the expression of BMAL1 and increases the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HepG2, C2C12 cells Concentration: 0-20 µM Incubation Time: 24 h Result: Showed no adverse effects on cell viability up to the maximum dose examined 20 µM. RT-PCRCell Line: HepG2 cells Concentration: 5 µM Incubation Time: 24 h Result: Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a. In Vivo STL1267 (50 mg/kg; i.p.; once) inhibits Bmal1 expression in mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks, male C57Bl/6 J mice Dosage: 50 mg/kg Administration: I.p.; once Result: Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration. Form:Solid IC50& Target:K i : 0.16 µM (REV-ERBα)

Names and Identifiers

Smiles	ClC1=NN=C2C=CC(OC3=C(C4=CC=CC=C4)C=CC=C3)=NN12
Molecular Weight	322.75

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