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SRX3207 - 10mM in DMSO, high purity , CAS No.2254693-15-5
Basic Description
| Specifications & Purity |
10mM in DMSO |
| Biochemical and Physiological Mechanisms |
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and inc |
| Storage Temp |
Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Information SRX3207 is an orally active dual inhibitor ofSyk-PI3Kwith IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM forSyk,Zap70,BRD41,BRD42,PI3K alpha,PI3K delta,PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity. Targets Syk (cell-free assay); PI3K alpha (cell-free assay); PI3K delta (cell-free assay); BRD41 (cell-free assay); BRD42 (cell-free assay) 32131,39.9 nM; 244 nM; 388 nM; 3070 nM; 3070 nM In vivo SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo. |
Product Properties
| ALogP |
4.59 |
| HBD Count |
1 |
| Rotatable Bond |
7 |
Names and Identifiers
| IUPAC Name |
3-[4-[[4-[4-(azetidin-1-ylmethyl)-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]phenyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one |
| INCHI |
InChI=1S/C29H29N7O3S/c1-19-21(16-34-9-2-10-34)17-36(33-19)25-7-8-30-29(32-25)31-22-5-3-20(4-6-22)23-18-40-28-24(37)15-26(39-27(23)28)35-11-13-38-14-12-35/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,30,31,32) |
| InChIKey |
ZZVOPDBZUNUMPR-UHFFFAOYSA-N |
| Smiles |
CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7 |
| PubChem CID |
137357450 |
| Molecular Weight |
555.65 |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| DMSO(mg / mL) Max Solubility |
33 |
| DMSO(mM) Max Solubility |
59.3899037163682 |
| Water(mg / mL) Max Solubility |
＜1 |
| Molecular Weight |
555.700 g/mol |
| XLogP3 |
4.000 |
| Hydrogen Bond Donor Count |
1 |
| Hydrogen Bond Acceptor Count |
10 |
| Rotatable Bond Count |
7 |
| Exact Mass |
555.205 Da |
| Monoisotopic Mass |
555.205 Da |
| Topological Polar Surface Area |
126.000 Ų |
| Heavy Atom Count |
40 |
| Formal Charge |
0 |
| Complexity |
923.000 |
| Isotope Atom Count |
0 |
| Defined Atom Stereocenter Count |
0 |
| Undefined Atom Stereocenter Count |
0 |
| Defined Bond Stereocenter Count |
0 |
| Undefined Bond Stereocenter Count |
0 |
| The total count of all stereochemical bonds |
0 |
| Covalently-Bonded Unit Count |
1 |
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