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SRT2183 - 99%, high purity , CAS No.1001908-89-9

COA

Grade & Purity:

≥99%

Cas Number: 1001908-89-9
Molecular Weight: 468.57
PubChem CID: 24180126
PubChem SID: 504769735

In stock

Item Number

S413956

Grouped product items
SKU	Size	Availability	Price
S413956-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$132.90
S413956-10mg	10mg	2	$216.90
S413956-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$488.90
S413956-50mg	50mg	1	$878.90
S413956-100mg	100mg	2	$1,581.90

SIRT1 Selective Inhibitors | Activators | Modulators

View related series

Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) Histone Modification (1379) Sirtuin (94)

Basic Description

Synonyms	DTXSID501029656 \| s8270 \| SRT 2183 \| SRT2183 \| SRT-2183 \| Q7392861 \| 6FKU9G9CX6 \| CS-0016574 \| HY-19759 \| EX-A4217 \| SCHEMBL1325303 \| N-[2-(3-{[(3R)-3-Hydroxy-1-pyrrolidinyl]methyl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-naphthamide \| HMS3886H08 \| 2-Nap
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information SRT2183 is a small-molecule activator of the sirtuin subtypeSIRT1, currently being developed by Sirtris Pharmaceuticals. Targets SIRT1 In vitro SRT2183 is potent with growth arrest and apoptosis induced at doses ranging from 1-20 μM. SRT2183 treatment leads to increased mRNA levels of pro-apoptosis, growth arrest, and DNA damage response genes. SRT1720, SRT2183, SRT1460, and resveratrol exhibit multiple off-target activities against receptors, enzymes, transporters, and ion channels. They are not direct activators of SIRT1. SRT2183 has little or no effect on SIRT1 deacetylating activity with native full-length substrates. SRT2183 activates AMPK, increases Sirt1 expression and decreases RelA/p65 lysine310 acetylation, critical for NF-κB activation, and an established Sirt1 target and inhibits RANKL-induced osteoclast generation and resorptive capacity in bone marrow macrophages. Cell Research(from reference) Cell lines：Bone-marrow derived macrophages(BMMs) Concentrations：1μM Incubation Time：72 h

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthalenecarboxylic acids and derivatives
      - Level5 Naphthalenecarboxamides
        Level6 Naphthalene-2-carboxanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthalenecarboxylic acids and derivatives
Intermediate Tree Nodes	Naphthalenecarboxamides
Direct Parent	Naphthalene-2-carboxanilides
Alternative Parents	Aromatic anilides Phenylimidazoles Aralkylamines N-substituted imidazoles N-alkylpyrrolidines Thiazoles Heteroaromatic compounds Trialkylamines Secondary carboxylic acid amides Secondary alcohols Amino acids and derivatives 1,2-aminoalcohols Azacyclic compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Naphthalene-2-carboxanilide - Aromatic anilide - 5-phenylimidazole - 4-phenylimidazole - Aralkylamine - N-substituted imidazole - Monocyclic benzene moiety - N-alkylpyrrolidine - Azole - Pyrrolidine - Thiazole - Heteroaromatic compound - Imidazole - Tertiary amine - Secondary carboxylic acid amide - 1,2-aminoalcohol - Tertiary aliphatic amine - Amino acid or derivatives - Secondary alcohol - Carboxamide group - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Amine - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthalene-2-carboxanilides. These are naphthalene-2-carboxamides, where the carboxamide group is substituted with an aniline.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.6
HBD Count	2
Rotatable Bond	5

Associated Targets(Human)

SIRT1 Tchem NAD-dependent protein deacetylase sirtuin-1 (1 Activities)

Discover Target: SIRT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT3 Tchem NAD-dependent deacetylase sirtuin 3 (1285 Activities)

Discover Target: SIRT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)

Discover Target: SIRT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504769735
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769735
IUPAC Name	N-[2-[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]naphthalene-2-carboxamide
INCHI	InChI=1S/C27H24N4O2S/c32-22-11-12-30(15-22)14-21-17-34-27-29-25(16-31(21)27)23-7-3-4-8-24(23)28-26(33)20-10-9-18-5-1-2-6-19(18)13-20/h1-10,13,16-17,22,32H,11-12,14-15H2,(H,28,33)/t22-/m1/s1
InChIKey	MUFSINOSQBMSLE-JOCHJYFZSA-N
Smiles	C1CN(CC1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5
Isomeric SMILES	C1CN(C[C@@H]1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5
PubChem CID	24180126
Molecular Weight	468.57

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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3 results found

Lot Number	Certificate Type	Date	Item
H2222155	Certificate of Analysis	Jun 09, 2025	S413956
H2222153	Certificate of Analysis	Jun 09, 2025	S413956
H2222154	Certificate of Analysis	Jun 09, 2025	S413956

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 93 mg/mL (198.47 mM); Ethanol: 3 mg/mL (6.4 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	93
DMSO(mM) Max Solubility	198.4762149
Water(mg / mL) Max Solubility	＜1
Molecular Weight	468.600 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	468.162 Da
Monoisotopic Mass	468.162 Da
Topological Polar Surface Area	98.100 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	725.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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