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SRT 1460 - 98%, high purity , CAS No.925432-73-1

COA

Grade & Purity:

≥98%

Cas Number: 925432-73-1
Molecular Weight: 507.62
PubChem CID: 24180124
PubChem SID: 504769734

In stock

Item Number

S334321

Grouped product items
SKU	Size	Availability	Price
S334321-1mg	1mg	3	$50.90
S334321-5mg	5mg	3	$107.90
S334321-10mg	10mg	3	$173.90
S334321-25mg	25mg	3	$249.90
S334321-50mg	50mg	2	$380.90
S334321-100mg	100mg	2	$576.90
S334321-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,298.90

a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1.

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) Histone Modification (1379) Sirtuin (94)

Basic Description

Synonyms	BRD-K20979596-019-01-6 \| MFCD19053214 \| SCHEMBL1302286 \| 3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)-imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide \| 3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide \| 3,4,5-TRIME
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SRT 1460 is a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1. SRT 1460 shows positive selectivity of SIRT1 versus SIRT2 and SIRT3. In animal studies, SRT 1460 was shown to have similar activity to resveratrol, a known SIRT1 activator. SRT 1460, however, is closer in potency to SRT 1720 than it is to resveratrol. SRT 1460 was observed in animal studies improving insulin sensitivity, lowering plasma glucose levels, and increasing metabolic function in mitochondria.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides
      - Level5 Aromatic anilides
        Level6 Benzanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Aromatic anilides
Direct Parent	Benzanilides
Alternative Parents	Phenylimidazoles Benzamides Anisoles Benzoyl derivatives Methoxybenzenes Phenoxy compounds N-alkylpiperazines Aralkylamines Alkyl aryl ethers N-substituted imidazoles Heteroaromatic compounds Thiazoles Amino acids and derivatives Trialkylamines Secondary carboxylic acid amides Azacyclic compounds Dialkylamines Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzanilide - 5-phenylimidazole - 4-phenylimidazole - Benzamide - Benzoic acid or derivatives - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Benzoyl - Alkyl aryl ether - N-alkylpiperazine - Aralkylamine - N-substituted imidazole - 1,4-diazinane - Piperazine - Thiazole - Imidazole - Heteroaromatic compound - Azole - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Ether - Secondary aliphatic amine - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Secondary amine - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SIRT3 Tchem NAD-dependent deacetylase sirtuin 3 (1285 Activities)

Discover Target: SIRT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)

Discover Target: SIRT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504769734
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769734
IUPAC Name	3,4,5-trimethoxy-N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide
INCHI	InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32)
InChIKey	SBEWVVLMFLTQFE-UHFFFAOYSA-N
Smiles	COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5
Isomeric SMILES	COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5
PubChem CID	24180124
Molecular Weight	507.62

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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7 results found

Lot Number	Certificate Type	Date	Item
F2204855	Certificate of Analysis	Mar 04, 2025	S334321
F2204956	Certificate of Analysis	Mar 04, 2025	S334321
F2204856	Certificate of Analysis	Mar 04, 2025	S334321
F2204859	Certificate of Analysis	Mar 04, 2025	S334321
F2204954	Certificate of Analysis	Mar 04, 2025	S334321
F2204857	Certificate of Analysis	Mar 04, 2025	S334321
F2204858	Certificate of Analysis	Mar 04, 2025	S334321

Chemical and Physical Properties

Molecular Weight	507.600 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	507.194 Da
Monoisotopic Mass	507.194 Da
Topological Polar Surface Area	118.000 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	714.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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