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SRI-42127 - 99%, high purity , CAS No.2727872-68-4

COA

Grade & Purity:

≥99%

Cas Number: 2727872-68-4
Molecular Weight: 348.40

In stock

Item Number

S649484

Grouped product items
SKU	Size	Availability	Price
S649484-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$220.90
S649484-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90
S649484-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$720.90
S649484-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,150.90

View related series

Immunology/Inflammation (1929) Interleukin Related (129) Non-coding RNA (59)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activat
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes In Vitro SRI-42127 (0.05-1 μM; 24 h) blocks HuR cytoplasmic translocation stimulated by LPS (1 μg/mL) in primary microglia. SRI-42127 (0.05-1 μM; 24 h) suppresses inflammatory cytokine and chemokine mRNA in activated Primary microglia cells (PMG). SRI-42127 (0.5 μM and 1 μM; 24 h) blocks glial-produced chemoattraction/migration signals for neutrophils and monocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SRI-42127 (15 mg/kg; i.p.; single dose) suppresses HuR translocation and the activation of microglia in mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HuR

Names and Identifiers

Smiles	CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5
Molecular Weight	348.40

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