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SRI-011381 hydrochloride - 99%, high purity , CAS No.2070014-88-7

COA

Grade & Purity:

≥99%

Cas Number: 2070014-88-7
Molecular Weight: 365.94
PubChem CID: 122198132

In stock

Item Number

S651921

Grouped product items
SKU	Size	Availability	Price
S651921-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
S651921-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$140.90
S651921-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
S651921-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
S651921-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$790.90

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Stem Cell/Wnt (1019) TGF-beta/Smad (303)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects In Vitro SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. Form:Solid IC50& Target:TGF-beta

Names and Identifiers

IUPAC Name	1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea;hydrochloride
INCHI	InChI=1S/C20H31N3O.ClH/c24-20(22-19-9-5-2-6-10-19)23(15-17-7-3-1-4-8-17)16-18-11-13-21-14-12-18;/h1,3-4,7-8,18-19,21H,2,5-6,9-16H2,(H,22,24);1H
InChIKey	GPNMJVSGNMDOJN-UHFFFAOYSA-N
Smiles	C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3.Cl
PubChem CID	122198132
Molecular Weight	365.94

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic) H2O : 25 mg/mL (68.32 mM; Need ultrasonic)
Molecular Weight	365.900 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	365.223 Da
Monoisotopic Mass	365.223 Da
Topological Polar Surface Area	44.400 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	369.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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