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Spectinomycin pentahydrate dihydrochloride - 10mM in DMSO, high purity , CAS No.22189-32-8, Bacterial 70S ribosome inhibitor
An aminocylcitol antibiotic
Basic Description
Synonyms
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | Trobicin | Spectinomycin hydrochloride | Spectogard | Spectinomycin HCl | Spectinomycin hydrochloride hydrate | Spectam | U 18,400AE | U-18,409AE | Espectinomicina dihydrochloride pentahydrate | Spectinomycin hcl pentah
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
An aminocyclcitol antibiotic . Active against Gram-positive and Gram-negative bacteria. Binds the 30S ribosome subunit and interrupts protein synthesis by interfering with peptidyl tRNA translocation.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Mechanism of action
Bacterial 70S ribosome inhibitor
Product Description
Used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr and to inhibit bacterial protein synthesis at the level of peptidy tRNA translocation
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Dioxanes
Subclass
1,4-dioxanes
Intermediate Tree Nodes
Not available
Direct Parent
1,4-dioxanes
Alternative Parents
Oxanes Secondary alcohols Ketones Hemiacetals Cyclic alcohols and derivatives 1,2-aminoalcohols Polyols Oxacyclic compounds Dialkylamines Acetals Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework
Aliphatic heteropolycyclic compounds
Substituents
Para-dioxane - Oxane - Cyclic alcohol - 1,2-aminoalcohol - Hemiacetal - Secondary alcohol - Ketone - Acetal - Secondary aliphatic amine - Oxacycle - Secondary amine - Polyol - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrochloride - Hydrocarbon derivative - Organic oxide - Carbonyl group - Amine - Alcohol - Organopnictogen compound - Organic oxygen compound - Aliphatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as 1,4-dioxanes. These are organic compounds containing 1,4-dioxane, an aliphatic six-member ring with two oxygen atoms in ring positions 1 and 4.
External Descriptors
hydrate - hydrochloride
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one;pentahydrate;dihydrochloride
INCHI
InChI=1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
InChIKey
DCHJOVNPPSBWHK-UXXUFHFZSA-N
Smiles
CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.O.O.O.O.O.Cl.Cl
Isomeric SMILES
C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O.O.O.O.O.O.Cl.Cl
WGK Germany
2
Alternate CAS
1695-77-8；21736-83-4
PubChem CID
30971
Molecular Weight
495.35
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
heat sensitive
Specific Rotation[α]
+15.0°～ +21.0°
Melt Point(°C)
207°C
Molecular Weight
495.300 g/mol
XLogP3
Hydrogen Bond Donor Count
12
Hydrogen Bond Acceptor Count
14
Rotatable Bond Count
2
Exact Mass
494.165 Da
Monoisotopic Mass
494.165 Da
Topological Polar Surface Area
135.000 Ų
Heavy Atom Count
30
Formal Charge
0
Complexity
478.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
9
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
8
Citations of This Product
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1 Citations