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Spautin-1 - 98% (HPLC), high purity , CAS No.1262888-28-7

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
S166799
Grouped product items
SKU Size
Availability
 Price Qty
S166799-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
S166799-10mg
10mg
2
$75.90
S166799-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$171.90
S166799-50mg
50mg
2
$271.90
S166799-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$489.90
S166799-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,102.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Cell-permeable USP10 and USP13 inhibitor

View related series
Apoptosis (4276) Autophagy (1917) Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Unfolded Protein Response (214)

Basic Description

Synonyms CS-4616 | A889470 | CS1815 | MBCQ derivative C43 | NCGC00263555-05 | deoxy-ATP, 2'-deoxyadenosine triphosphate, Deoxyadenosine 5'-triphosphate | EN300-93027 | P2613 | Spautin-1 | CCG-267171 | 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine | HMS3871D13 | EN
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in va
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Application：

Spautin-1 has been used as an autophagy inhibitor: to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model; to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin; to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazanaphthalenes
Subclass Benzodiazines
Intermediate Tree Nodes Quinazolines
Direct Parent Quinazolinamines
Alternative Parents Benzylamines  Fluorobenzenes  Aminopyrimidines and derivatives  Imidolactams  Aryl fluorides  Heteroaromatic compounds  Azacyclic compounds  Organofluorides  Hydrocarbon derivatives  Amines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinazolinamine - Benzylamine - Aminopyrimidine - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors Not available

Associated Targets(Human)

USP13 Tchem Ubiquitin carboxyl-terminal hydrolase 13 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
USP10 Tchem Ubiquitin carboxyl-terminal hydrolase 10 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-9 (1037 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C3 Tchem Phosphatidylinositol 3-kinase catalytic subunit type 3 (535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP10 Tchem Ubiquitin carboxyl-terminal hydrolase 10 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP13 Tchem Ubiquitin carboxyl-terminal hydrolase 13 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504771006
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771006
IUPAC Name 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
INCHI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChIKey AWIVHRPYFSSVOG-UHFFFAOYSA-N
Smiles C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F
Isomeric SMILES C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F
WGK Germany 3
PubChem CID 51037431
Molecular Weight 271.26

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
J2119649 Certificate of Analysis Aug 09, 2024 S166799
J2119654 Certificate of Analysis Aug 09, 2024 S166799
J2119656 Certificate of Analysis Aug 09, 2024 S166799
D2318442 Certificate of Analysis Aug 26, 2021 S166799
G2430006 Certificate of Analysis Aug 26, 2021 S166799

Chemical and Physical Properties

Sensitivity heat & air sensitive
Melt Point(°C) 211 °C
Molecular Weight 271.260 g/mol
XLogP3 3.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 3
Exact Mass 271.092 Da
Monoisotopic Mass 271.092 Da
Topological Polar Surface Area 37.800 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 307.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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