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SN6 - 98%, high purity , CAS No.415697-08-4

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S303682
Grouped product items
SKU Size
Availability
 Price Qty
S303682-5mg
5mg
3
$165.90
S303682-25mg
25mg
2
$494.90
S303682-50mg
50mg
2
$785.90
S303682-100mg
100mg
2
$1,261.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Selective Na+/Ca2+exchange inhibitor (reverse mode)

View related series
Membrane Transporter/Ion Channel (1822) Na+/Ca2+ Exchanger (12)

Basic Description

Synonyms BCP32885 | Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate | N16889 | BRD-A14316475-001-01-5 | HMS3677K09 | SN-6 | HY-107658 | CS-0029062 | DTXSID70436978 | HMS3413K09 | HMS3268P11 | SN 6; SN6 | SN-6, >=98% (HPLC) | AKOS024456975 | NCGC00
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50values are 2.9, 16 and 8.6μM for inhibition of intracellular Na+-dependent45Ca2+uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh re
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

SN-6 has been used as a selective Na+/Ca++ exchanger (NCX) inhibitor to study its neuroprotective effects on axonal injury in mice.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Alpha amino acid esters
Alternative Parents Nitrobenzenes  Nitroaromatic compounds  Phenoxy compounds  Phenol ethers  Alkyl aryl ethers  Thiazolidines  Carboxylic acid esters  Thiohemiaminal derivatives  Azacyclic compounds  Secondary amines  Dialkylthioethers  Monocarboxylic acids and derivatives  Organic oxoazanium compounds  Propargyl-type 1,3-dipolar organic compounds  Hydrocarbon derivatives  Organic salts  Organic oxides  Carbonyl compounds  Organic cations  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Alpha-amino acid ester - Nitrobenzene - Phenoxy compound - Nitroaromatic compound - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Thiazolidine - Carboxylic acid ester - C-nitro compound - Organic nitro compound - Ether - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organic oxoazanium - Secondary amine - Dialkylthioether - Thioether - Hemithioaminal - Organic 1,3-dipolar compound - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organonitrogen compound - Organooxygen compound - Organic salt - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Amine - Organic oxide - Organic cation - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
External Descriptors Not available

Associated Targets(Human)

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504765339
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504765339
IUPAC Name ethyl 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-1,3-thiazolidine-4-carboxylate
INCHI InChI=1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
InChIKey ZVYIJXLMBWCGHP-UHFFFAOYSA-N
Smiles CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-]
Isomeric SMILES CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-]
PubChem CID 10222761
Molecular Weight 402.46

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
C2308058 Certificate of Analysis Nov 19, 2022 S303682
C2308060 Certificate of Analysis Nov 19, 2022 S303682
C2526193 Certificate of Analysis Nov 19, 2022 S303682
C2308059 Certificate of Analysis Nov 19, 2022 S303682
C2308067 Certificate of Analysis Nov 19, 2022 S303682

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 40.22, Max Conc. mM: 100
Sensitivity Moisture sensitive.
Molecular Weight 402.500 g/mol
XLogP3 4.000
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 8
Exact Mass 402.125 Da
Monoisotopic Mass 402.125 Da
Topological Polar Surface Area 119.000 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 513.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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