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SN 2 - ≥98%(HPLC), high purity , CAS No.823218-99-1, Activator of TRPML3

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 823218-99-1
Molecular Weight: 255.35
PubChem CID: 11834987
PubChem SID: 488197778

In stock

Item Number

S287484

Grouped product items
SKU	Size	Availability	Price
S287484-5mg	5mg	3	$89.90
S287484-10mg	10mg	1	$144.90
S287484-25mg	25mg	1	$326.90
S287484-50mg	50mg	1	$610.90
S287484-100mg	100mg	1	$1,099.90

Selective TRPML3 channel activator

View related series

Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181) TRPML3 Activator (10)

Basic Description

Synonyms	GTPL6402 \| Q27088829 \| 5-mesityl-3-oxa-4-azatricyclo[5.2.1.0~2,6~]dec-4-ene \| 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclo[5.2.1.0?,?]dec-4-ene \| 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene \| AE-842/34023054 \| SN 2 \| DTXSID50133663
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective TRPML3 channel activator (EC50= 1.13μM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPML3
Product Description	Product Describtion: SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Prenol lipids
    - Subclass Monoterpenoids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Monoterpenoids
Intermediate Tree Nodes	Not available
Direct Parent	Aromatic monoterpenoids
Alternative Parents	Benzene and substituted derivatives Isoxazolines Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Aromatic monoterpenoid - Benzenoid - Monocyclic benzene moiety - Isoxazoline - Oxacycle - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MCOLN3 Tchem Mucolipin-3 (2 Activities)

Discover Target: MCOLN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCOLN3 Tchem MCOLN3 protein (319 Activities)

Discover Target: MCOLN3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

nompc Ion channel NompC (277 Activities)

Discover Target: nompc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488197778
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488197778
IUPAC Name	5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
INCHI	InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3
InChIKey	WKLZNTYMDOPBSE-UHFFFAOYSA-N
Smiles	CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
Isomeric SMILES	CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
Alternate CAS	823218-99-1
PubChem CID	11834987
Molecular Weight	255.35

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
D2312653	Certificate of Analysis	Mar 01, 2023	S287484
D2312674	Certificate of Analysis	Mar 01, 2023	S287484
D2312646	Certificate of Analysis	Mar 01, 2023	S287484
D2313464	Certificate of Analysis	Mar 01, 2023	S287484
D2312652	Certificate of Analysis	Mar 01, 2023	S287484
C23241152	Certificate of Analysis	Mar 01, 2023	S287484
D2313460	Certificate of Analysis	Mar 01, 2023	S287484
D2313461	Certificate of Analysis	Mar 01, 2023	S287484
D2313462	Certificate of Analysis	Mar 01, 2023	S287484
D2312678	Certificate of Analysis	Mar 01, 2023	S287484
D2313463	Certificate of Analysis	Mar 01, 2023	S287484

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 25.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 25.53, Max Conc. mM: 100
Molecular Weight	255.350 g/mol
XLogP3	4.300
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	255.162 Da
Monoisotopic Mass	255.162 Da
Topological Polar Surface Area	21.600 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	392.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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