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SMER3 - ≥98%, high purity , CAS No.67200-34-4

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S275012
Grouped product items
SKU Size
Availability
 Price Qty
S275012-10mg
10mg
3
$107.90
S275012-50mg
50mg
3
$325.90
S275012-250mg
250mg
3
$1,467.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Cell-permeable, selective SCF Met30 ubiquitin E3 ligase inhibitor

View related series
Amino Acid/Protein Metabolism (1836) E1/E2/E3 Enzyme (112) e3 ligase (1) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms 13-oxa-10,12,14,16-tetraazatetracyclo[7.7.0.0^{2,7}.0^{11,15}]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one | HY-10949 | Oprea1_783821 | US9073941, 28 | Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one | ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitro-2-thienyl)methyl]a
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Cell permeable, selective SCF Met30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC 50 = 10-30 μM). Active in vivo.
Source Synthetic
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbonyl compounds
Intermediate Tree Nodes Ketones
Direct Parent Aryl ketones
Alternative Parents Pyrazines  Benzenoids  Heteroaromatic compounds  Furazans  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Aryl ketone - Benzenoid - Pyrazine - Heteroaromatic compound - Oxadiazole - Furazan - Azole - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as aryl ketones. These are organic aromatic compounds that contain a ketone group substituted at one C-atom with an aryl group. They have the generic structure RC(=O)R', where R = aryl group and R'=organyl group.
External Descriptors Not available

Associated Targets(Human)

NQO1 Tchem Quinone reductase 1 (1746 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTNNB1 Tchem Catenin beta-1 (517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BIRC5 Tchem Baculoviral IAP repeat-containing protein 5 (144 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L02 (4864 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP C4-2 (165 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

PTGES Prostaglandin E synthase (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (54 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504759296
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504759296
IUPAC Name 13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
INCHI InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChIKey SFSSAKVWCKFRHE-UHFFFAOYSA-N
Smiles C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
Isomeric SMILES C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
PubChem CID 568763
Molecular Weight 224.18

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
F2518100 Certificate of Analysis Jun 24, 2025 S275012
G2229210 Certificate of Analysis May 10, 2023 S275012
G2229211 Certificate of Analysis May 10, 2023 S275012
G2229212 Certificate of Analysis May 10, 2023 S275012

Chemical and Physical Properties

Solubility Soluble in DMSO to 100 mM
Sensitivity Heat sensitive
Melt Point(°C) 296 °C
Molecular Weight 224.170 g/mol
XLogP3 1.200
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 0
Exact Mass 224.033 Da
Monoisotopic Mass 224.033 Da
Topological Polar Surface Area 81.800 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 350.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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