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SM1-71 - 10mM in DMSO, high purity , CAS No.2088179-99-9(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2088179-99-9(DMSO)
Molecular Weight: 463.96

In stock

Item Number

S654614

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SKU	Size	Availability	Price	Qty
S654614-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$82.90

View related series

Cell Cycle/DNA Damage (2602) Compound libraries (12325) FGFR (112) LIM Kinase (LIMK) (14) MAP3K (30) MAPK/ERK Pathway (546) Protein Tyrosine Kinase/RTK (1314) Ribosomal S6 Kinase (RSK) (34) Src (93)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	SM1-71 (compound 5) is a potent TAK1 inhibitor, with a K i of 160 nM, it also can covalently inhibit MKNK2 , MAP2K1/2/3/4/6/7 , GAK , AAK1 , BMP2K , MAP3K7 , MAPKAPK5 , GSK3A/B , MAPK1/3 , SRC , YES1 , FGFR1 , ZAK (MLTK) , MAP3K1 , LIMK1 and RSK2 . SM1-71
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SM1-71 (compound 5) is a potent TAK1 inhibitor, with a K i of 160 nM, it also can covalently inhibit MKNK2 , MAP2K1/2/3/4/6/7 , GAK , AAK1 , BMP2K , MAP3K7 , MAPKAPK5 , GSK3A/B , MAPK1/3 , SRC , YES1 , FGFR1 , ZAK (MLTK) , MAP3K1 , LIMK1 and RSK2 . SM1-71 can inhibit proliferation of multiple cancer cell lines In Vitro SM1-71 (0.001-100 μM; 72 h) potently inhibits the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines with a concentration-dependent manner. SM1-71 (72 h) induces potent cytotoxicity with nanomolar values for GR 50 and negative GR max values in eight of 11 cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: H23-KRAS G12C and Calu-6-KRAS Q61K cells Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 72 hours Result: Inhibited proliferation of H23-KRAS G12C and Calu-6-KRAS Q61K cells with IC 50 s of 0.4 and 0.3 μM, respectively. IC50& Target:IC50: 0.8 nM (GAK), 0.8 nM (YES1), 2 nM (SRC), 4.4 nM (AAK1), 5.4 nM (LIMK1), 7.1 nM (BMP2K), 9.3 nM (MAP2K2), 10.4 nM (MAP2K1), 28.7 nM (MAP3K1), 48.3 nM (MAPK1), 107 nM (MAPK3)

Associated Targets(Human)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src (0 Activities)

Discover Target: SRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K7 Tchem Mitogen-activated protein kinase kinase kinase 7 (0 Activities)

Discover Target: MAP3K7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NC(=O)C=C)Cl
Molecular Weight	463.96

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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