Skip to the beginning of the images gallery

SLU-PP-915 - 98%, high purity , CAS No.2285432-92-8

COA

Grade & Purity:

≥98%

Cas Number: 2285432-92-8
Molecular Weight: 341.16

In stock

Item Number

S657035

Grouped product items
SKU	Size	Availability	Price
S657035-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
S657035-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
S657035-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
S657035-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90
S657035-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90

View related series

Estrogen Receptor/ERR (213) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SLU-PP-915 is an agonist of ERR . SLU-PP-915 has an EC 50 value of approximately 400 nM for ERRα , ERRβ , and ERRγ . SLU-PP-915 has potential application in maintaining oxidative metabolism and heart failure. Form:Solid In Vitro:SLU-PP-915 (2.5 µM; 72 h) increases the gene and protein expression of transcription factor EB (TFEB) in neonatal rat ventricular myocytes (NRVMs). SLU-PP-915 (5 µM) increases the expression of TFEB gene (at 3 h) and TFEB protein (at 72 h) in C 2 C 12 cells. SLU-PP-915 (5 µM; 48 h or 72 h) increases the expression of PGC1a, p62, PDK4, CTSD, LAMP1, LAMP2 and MCOLN1 ERR target genes in C 2 C 12 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Neonatal rat ventricular myocytes (NRVMs) and C 2 C 12 cells. Concentration: 2.5 µM and 5 µM. Incubation Time: 72 h. Result: Increased the expression of TFEB and LAMP1. ImmunofluorescenceCell Line: C 2 C 12 cells. Concentration: 5 µM. Incubation Time: 48 h. Result: Increased the expression of TFEB. In Vivo:SLU-PP-915 improves transaortic constriction (TAC) induced heart failure in adult male mice [1] . SLU-PP-915 significantly normalizes the metabolic profile of fatty acids/lipids and TCA/OXPHOS metabolites in the heart of mice with 6-week pressure overload. SLU-PP-915 improves the blood pumping function in vivo in TAC induced heart failure without affecting cardiac hypertrophy [2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Males C57BI/6J mice (8 weeks of age) [2] . Dosage: 20 mg/kg. Administration: Intraperitoneal injection; single dose. Result: Pharmacokinetic (PK) parameters of SLU-PP-915 in mice T max (h) C max (ng/mL) AUC last (h•ng/mL) V z /F (L/kg) CL/F (mL/min/kg) T 1/2 (h) 0.5 2813 1846 11 179 0.71

Names and Identifiers

Smiles	O=C(C1=CC=C(C2=CC(B(O)O)=CC=C2)S1)NC3=C(F)C=CC=C3
Molecular Weight	341.16

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration