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SKLB1002 - 98%, high purity , CAS No.1225451-84-2

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S347904
Grouped product items
SKU Size
Availability
 Price Qty
S347904-5mg
5mg
2
$237.90
S347904-25mg
25mg
2
$1,068.90
S347904-100mg
100mg
2
$3,847.90
S347904-500mg
500mg
2
$17,313.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Cell signal transduction and Neuroscience (85) Receptor tyrosine kinase (RTK) inhibitors (18)

Basic Description

Synonyms 2-((6,7-Dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole | 6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]quinazoline | A891099 | SKLB1002 | SKLB-1002 | 1225451-84-2 | 2-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-5-methyl-1,3,4-thiadiazole
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms SKLB1002 is a cell permeable and potent VEGFR2 inhibitor that potently inhibits HUVEC cells proliferation, migration, invasion, and tube formation. It appears that SKLB1002 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organosulfur compounds
Class Thioethers
Subclass Aryl thioethers
Intermediate Tree Nodes Not available
Direct Parent Diarylthioethers
Alternative Parents Quinazolines  Anisoles  Alkyl aryl ethers  Pyrimidines and pyrimidine derivatives  Thiadiazoles  Heteroaromatic compounds  Sulfenyl compounds  Azacyclic compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Diarylthioether - Quinazoline - Anisole - Phenol ether - Alkyl aryl ether - Pyrimidine - Benzenoid - Azole - Heteroaromatic compound - Thiadiazole - Ether - Azacycle - Organoheterocyclic compound - Sulfenyl compound - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups.
External Descriptors Not available

Associated Targets(Human)

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW-620 (52400 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Danio rerio (3092 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772118
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772118
IUPAC Name 2-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-5-methyl-1,3,4-thiadiazole
INCHI InChI=1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3
InChIKey RQVGFDBMONQTBC-UHFFFAOYSA-N
Smiles CC1=NN=C(S1)SC2=NC=NC3=CC(=C(C=C32)OC)OC
Isomeric SMILES CC1=NN=C(S1)SC2=NC=NC3=CC(=C(C=C32)OC)OC
PubChem CID 71461003
Molecular Weight 320.39

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
I2216440 Certificate of Analysis Jun 16, 2025 S347904
I2216441 Certificate of Analysis Jun 10, 2025 S347904
I2216442 Certificate of Analysis Jun 10, 2025 S347904
I2216443 Certificate of Analysis Jun 10, 2025 S347904

Chemical and Physical Properties

Solubility insoluble in H2O; ≥5 mg/mL in EtOH with gentle warming and ultrasonic; ≥8 mg/mL in DMSO
Melt Point(°C) 193 °C
Molecular Weight 320.400 g/mol
XLogP3 3.100
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 4
Exact Mass 320.04 Da
Monoisotopic Mass 320.04 Da
Topological Polar Surface Area 124.000 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 352.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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