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SKLB 610 - 98%, high purity , CAS No.1125780-41-7

COA

Grade & Purity:

≥98%

Cas Number: 1125780-41-7
Molecular Weight: 415.37
PubChem CID: 25230662
PubChem SID: 504770032

In stock

Item Number

S413502

Grouped product items
SKU	Size	Availability	Price
S413502-5mg	5mg	3	$193.90
S413502-10mg	10mg	2	$343.90
S413502-25mg	25mg	2	$735.90
S413502-50mg	50mg	2	$1,201.90
S413502-100mg	100mg	2	$1,716.90

VEGFR2 Selective Inhibitors

Basic Description

Synonyms	SKLB 610 \| N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information SKLB-610 is a multi-target inhibitor of thetyrosine kinases. It is most potent againstVEGFR2and exhibits slightly weaker inhibitor ofFGFR2 and PDGFR. Targets VEGFR2 ; FGFR2 ; PDGFR ; PDGFR ; FGFR2 In vitro SKLB610 shows selective inhibition of VEGF-stimulated human umbilical vein endothelial cells (HUVECs) proliferation, and this proliferation inhibitory effect is associated with decreased phosphorylation of VEGFR2 and p42/44 mitogen-activated protein kinase (p42/44 MAPK). SKLB610 inhibits a panel of human cancer cells proliferation in a concentration-dependent manner and human nonsmall cell lung cancer cell line A549 and human colorectal cancer cell line HCT116 are most sensitive to SKLB610 treatment. At concentration of 10μM, SKLB610 inhibits 65% FGFR2 activity and 55% PDGFRE activity, respectively. Relative to PDGFR2 and FGFR2 SKLB610 has more selective inhibition of VEGFR2 which shows 97% inhibition of VEGFR2 activity at 10μM in vitro. No inhibition of enzyme activity is detected when 10μM of SKLB610 is examined against PI3K, EGFR, Aurora-A, CDK2/cyclinE and CDK6/cyclinD3. In vivo chronic intraperitoneally administration of SKLB610 at dose of 50mg/kg/d results in significant inhibition in the growth of established human A549 and HCT116 tumor xenografts in nude mice without exhibit toxicity.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides
      - Level5 Aromatic anilides
        Level6 Benzanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Aromatic anilides
Direct Parent	Benzanilides
Alternative Parents	Diarylethers Trifluoromethylbenzenes Benzamides Pyridinecarboxamides 2-heteroaryl carboxamides Benzoyl derivatives Phenoxy compounds Phenol ethers Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Alkyl fluorides Organic oxides Organofluorides Organonitrogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzanilide - Diaryl ether - Trifluoromethylbenzene - Benzamide - Benzoic acid or derivatives - Pyridinecarboxamide - Pyridine carboxylic acid or derivatives - 2-heteroaryl carboxamide - Phenoxy compound - Benzoyl - Phenol ether - Pyridine - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Ether - Alkyl fluoride - Organohalogen compound - Organofluoride - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.603
HBD Count	2
Rotatable Bond	6

Associated Targets(Human)

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770032
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770032
IUPAC Name	N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide
INCHI	InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
InChIKey	WACDHHMEVMSODJ-UHFFFAOYSA-N
Smiles	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F
Isomeric SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F
PubChem CID	25230662
Molecular Weight	415.37

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
H2203708	Certificate of Analysis	May 12, 2025	S413502
H2203709	Certificate of Analysis	May 12, 2025	S413502
H2203707	Certificate of Analysis	May 12, 2025	S413502
H2203710	Certificate of Analysis	May 12, 2025	S413502
H2203706	Certificate of Analysis	May 12, 2025	S413502

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 83 mg/mL (199.82 mM); Ethanol: 27 mg/mL (65.0 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	83
DMSO(mM) Max Solubility	199.821845583456
Water(mg / mL) Max Solubility	＜1
Molecular Weight	415.400 g/mol
XLogP3	3.700
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	415.114 Da
Monoisotopic Mass	415.114 Da
Topological Polar Surface Area	80.300 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	594.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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