JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Account

Settings

Language

྾

Home
Applications
Protein kinases
CMGC:Containing CDK, MAPK, GSK3, CLK families
SKL2001 - 99%, high purity , CAS No.909089-13-0

Skip to the end of the images gallery

Skip to the beginning of the images gallery

SKL2001 - 99%, high purity , CAS No.909089-13-0

COA

Grade & Purity:

≥99%

Cas Number: 909089-13-0
Molecular Weight: 286.29
PubChem CID: 16003447
PubChem SID: 504768000

In stock

Item Number

S413970

Grouped product items
SKU	Size	Availability	Price
S413970-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$68.90
S413970-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$286.90
S413970-250mg	250mg	2	$1,291.90

Wnt/beta-catenin Agonists

View related series

Stem Cell/Wnt (1019) Wnt (104) β-catenin (56)

Basic Description

Synonyms	3-Isoxazolecarboxamide,5-(2-furanyl)-N-[3-(1H-imidazol-1-yl)propyl]-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information SKL2001 SKL2001 is a novel agonist of the Wnt/β-catenin pathway . It disrupts the Axin/β-catenin interaction. Targets Wnt/β-catenin (Cell-free assay) In vitro SKL2001 upregulated β-catenin responsive transcription by increasing the intracellular β-catenin protein level and inhibited the phosphorylation of β-catenin at residues Ser33/37/Thr41 and Ser45, which would mark it for proteasomal degradation, without affecting CK1 and GSK-3β enzyme activities. SKL2001 disrupted the Axin/β-catenin interaction, which is a critical step for CK1- and GSK-3β-mediated phosphorylation of β-catenin at Ser33/37/Thr41 and Ser45. The treatment of mesenchymal stem cells with SKL2001 promoted osteoblastogenesis and suppressed adipocyte differentiation, both of which were accompanied by the activation of Wnt/β-catenin pathway. SKL2001 did not affect either NF-κB or p53 reporter activity and inhibits β-catenin phosphorylation without affecting GSK-3β activity. Cell Research(from reference) Cell lines：HEK293 reporter and control cell lines Concentrations：20 μM Incubation Time：15 h

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Carboxylic acid derivatives
      - Level5 Carboxylic acid amides
        Level6 2-heteroaryl carboxamides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Carboxylic acid derivatives
Intermediate Tree Nodes	Carboxylic acid amides
Direct Parent	2-heteroaryl carboxamides
Alternative Parents	N-substituted imidazoles Isoxazoles Heteroaromatic compounds Furans Secondary carboxylic acid amides Oxacyclic compounds Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-heteroaryl carboxamide - N-substituted imidazole - Azole - Furan - Imidazole - Isoxazole - Heteroaromatic compound - Secondary carboxylic acid amide - Oxacycle - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2-heteroaryl carboxamides. These are compounds containing a heteroaromatic ring that carries a carboxamide group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	0.929
HBD Count	1
Rotatable Bond	6

Names and Identifiers

Pubchem Sid	504768000
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768000
IUPAC Name	5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide
INCHI	InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
InChIKey	PQXINDBPUDNMPE-UHFFFAOYSA-N
Smiles	C1=COC(=C1)C2=CC(=NO2)C(=O)NCCCN3C=CN=C3
Isomeric SMILES	C1=COC(=C1)C2=CC(=NO2)C(=O)NCCCN3C=CN=C3
PubChem CID	16003447
Molecular Weight	286.29

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot Number	Certificate Type	Date	Item
H2222156	Certificate of Analysis	Jun 09, 2025	S413970

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 57 mg/mL (199.09 mM); Ethanol: 57 mg/mL (199.09 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	57
DMSO(mM) Max Solubility	199.0988159
Water(mg / mL) Max Solubility	＜1
Molecular Weight	286.290 g/mol
XLogP3	0.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	286.107 Da
Monoisotopic Mass	286.107 Da
Topological Polar Surface Area	86.100 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	355.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.