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SKF-34288 hydrochloride - 10mM in Water, high purity , CAS No.320386-54-7(Water)

COA

Grade & Purity:

10mM in Water

Cas Number: 320386-54-7(Water)
Molecular Weight: 191.64

In stock

Item Number

S656285

Grouped product items
SKU	Size	Availability	Price	Qty
S656285-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$316.90

View related series

Compound libraries (12325) Metabolic Enzyme/Protease (4860) PEPCK (3)

Basic Description

Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride a
Storage Temp	Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides In Vitro SKF-34288 hydrochloride (0.01-1 mM, 48 h) inhibits C2C12 cell proliferation . SKF-34288 hydrochloride (0.25-1 mM, 0-5 day) induces myogenic differentiation of C2C12 cells . SKF-34288 hydrochloride (0.25 or 1 mM) reduces mRNA expression of Pck2 and genes associated with serine biosynthesis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: C2C12 cell Concentration: 0, 0.01, 0.1, 0.25, 0.5, 1 mM Incubation Time: 48 h Result: Dose-dependently inhibited C2C12 cell proliferation. In Vivo SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats . SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits. SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Starved rats Dosage: 37.5, 75 and 150mg/kg Administration: Oral administration (p.o.) Result: Showed dose-dependent magnitude and duration of the hypoglycaemic effect. IC50& Target:Ki: 2-9 μM (PEPCK)

Names and Identifiers

Smiles	C1=CC(=C(N=C1)C(=O)O)S.Cl
Molecular Weight	191.64

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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