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SKA-31 - 97%, high purity , CAS No.40172-65-4, Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

COA

Grade & Purity:

Moligand™

≥97%

Cas Number: 40172-65-4
Molecular Weight: 200.26
MDL number: MFCD00051329
PubChem CID: 94880

In stock

Item Number

N135127

Grouped product items
SKU	Size	Availability	Price
N135127-25mg	25mg	3	$231.90
N135127-50mg	50mg	3	$385.90
N135127-250mg	250mg	2	$1,737.90
N135127-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$6,253.90

K Ca 3.1 and K Ca 2 channel activator

View related series

KCa2.1 Activator (7) KCa2.2 Activator (10) KCa2.3 Activator (8) KCa3.1 Activator (10) Membrane Transporter/Ion Channel (1822) Potassium Channel (253)

Basic Description

Synonyms	benzo[e][1,3]benzothiazol-2-amine \| 2-Aminonaphthiazole \| F1386-0401 \| BDBM31193 \| Ici-118,587 hemifumarate \| 2-Amino-.beta.-naphthothiazole \| Guggulsterone, (E)- \| HB1050 \| 2-Aminonaphtho(1,2-d)thiazole \| 2-AMINO-NAPHTHO[1,2-D]THIAZOLE \| 2-Aminonaphtho[1
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in exper
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Naphthothiazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Naphthothiazoles
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Naphthothiazoles
Alternative Parents	Naphthalenes Benzothiazoles 2-amino-1,3-thiazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Naphthothiazole - Naphthalene - 1,3-benzothiazole - Benzenoid - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Azacycle - Primary amine - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthothiazoles. These are polycyclic aromatic compounds containing a thiazole fused to a naphthalene. Thiazole is a 5-membered aromatic ring containing three carbon, one oxygen, and one nitrogen atom. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (1 Activities)

Discover Target: KCNN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 (1 Activities)

Discover Target: KCNN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (1 Activities)

Discover Target: KCNN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

Discover Target: GNAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)

Discover Target: BRCA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNCA Tchem Alpha-synuclein (10960 Activities)

Discover Target: SNCA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

Discover Target: clpP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	benzo[e][1,3]benzothiazol-2-amine
INCHI	InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChIKey	FECQXVPRUCCUIL-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)C=CC3=C2N=C(S3)N
Isomeric SMILES	C1=CC=C2C(=C1)C=CC3=C2N=C(S3)N
Molecular Weight	200.26
Reaxy-Rn	152877
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=152877&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
L2216923	Certificate of Analysis	Jan 06, 2023	N135127
L2216920	Certificate of Analysis	Dec 26, 2022	N135127
L2216918	Certificate of Analysis	Dec 26, 2022	N135127
G2014053	Certificate of Analysis	May 10, 2022	N135127

Chemical and Physical Properties

Solubility	solubility DMSO: ≥30 mg/mL
Molecular Weight	200.260 g/mol
XLogP3	3.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	200.041 Da
Monoisotopic Mass	200.041 Da
Topological Polar Surface Area	67.200 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	221.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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