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SJB2-043 - 2mM in DMSO, high purity , CAS No.63388-44-3, Inhibitor of ubiquitin specific peptidase 1
Basic Description
Synonyms
sjb2-043 | 63388-44-3 | 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE | 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione | CHEMBL3407552 | SJB2 043 | 2-Phenyl-naphth[2,3-d]oxazole-4,9-dione | 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione | SCHEMBL7808226 | GTPL12225 | DTXSID40333501 | SJB2043 |
Specifications & Purity
Moligand™, 2mM in DMSO
Biochemical and Physiological Mechanisms
IC50 Value: 0.544 uM (USP1)
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of ubiquitin specific peptidase 1
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Azoles
Subclass
Oxazoles
Intermediate Tree Nodes
Not available
Direct Parent
Phenyl-1,3-oxazoles
Alternative Parents
Naphthalenes Aryl ketones Benzene and substituted derivatives Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Phenyl-1,3-oxazole - Naphthalene - Aryl ketone - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Ketone - Oxacycle - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
INCHI
InChI=1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChIKey
CMYQQADDUUDCCA-UHFFFAOYSA-N
Smiles
C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
Isomeric SMILES
C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
PubChem CID
509070
Molecular Weight
275.26
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
275.260 g/mol
XLogP3
3.600
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
1
Exact Mass
275.058 Da
Monoisotopic Mass
275.058 Da
Topological Polar Surface Area
60.200 Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
443.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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