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SJB2-043 - 98%, high purity , CAS No.63388-44-3, Inhibitor of ubiquitin specific peptidase 1

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SJB2-043 - 98%, high purity , CAS No.63388-44-3, Inhibitor of ubiquitin specific peptidase 1

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 63388-44-3
Molecular Weight: 275.26
PubChem CID: 509070
PubChem SID: 504758959

In stock

Item Number

S126106

Grouped product items
SKU	Size	Availability	Price
S126106-1mg	1mg	3	$130.90
S126106-5mg	5mg	3	$276.90
S126106-10mg	10mg	3	$420.90
S126106-25mg	25mg	2	$947.90
S126106-50mg	50mg	2	$997.90
S126106-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,662.90

View related series

Cell Cycle/DNA Damage (2602) Deubiquitinase (86) ubiquitin specific peptidase 1 Inhibitor (4)

Basic Description

Synonyms	AC-36369 \| AKOS027254768 \| 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione \| 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE \| MFCD26960957 \| 2-phenyl-naphthoxazole-4,9-quinone \| A917582 \| GTPL12225 \| SJB2043 \| sjb2-043 \| 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione \| CS-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	IC50 Value: 0.544 uM (USP1) SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin specific peptidase 1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Oxazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Oxazoles
Intermediate Tree Nodes	Not available
Direct Parent	Phenyl-1,3-oxazoles
Alternative Parents	Naphthalenes Aryl ketones Benzene and substituted derivatives Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenyl-1,3-oxazole - Naphthalene - Aryl ketone - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Ketone - Oxacycle - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (1 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504758959
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758959
IUPAC Name	2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
INCHI	InChI=1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChIKey	CMYQQADDUUDCCA-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
Isomeric SMILES	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
PubChem CID	509070
Molecular Weight	275.26

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2210188	Certificate of Analysis	Dec 20, 2023	S126106
C2210193	Certificate of Analysis	Dec 20, 2023	S126106
C2210190	Certificate of Analysis	Dec 20, 2023	S126106
C2210191	Certificate of Analysis	Dec 20, 2023	S126106
C2210192	Certificate of Analysis	Dec 20, 2023	S126106
C2210663	Certificate of Analysis	Dec 20, 2023	S126106

Chemical and Physical Properties

Solubility	insoluble in H2O; insoluble in EtOH; ≥6.68 mg/mL in DMSO
Molecular Weight	275.260 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	275.058 Da
Monoisotopic Mass	275.058 Da
Topological Polar Surface Area	60.200 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	443.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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