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Sivelestat sodium salt - ≥98%(HPLC), high purity , CAS No.150374-95-1

2 Citations

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 150374-95-1
Molecular Weight: 456.44
PubChem CID: 23664980
PubChem SID: 504769500

In stock

Item Number

S287743

Grouped product items
SKU	Size	Availability	Price
S287743-5mg	5mg	3	$49.90
S287743-10mg	10mg	3	$82.90
S287743-25mg	25mg	3	$186.90
S287743-50mg	50mg	3	$284.90
S287743-100mg	100mg	3	$513.90

Selective leukocyte elastase inhibitor

View related series

Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Elastase (31) Metabolic Enzyme/Protease (4860) SARS-CoV (200) Virus (1811)

Basic Description

Synonyms	Sivelestat (sodium) \| HY-17443A \| NCGC00261500-01 \| SIVELESTAT SODIUM SALT ANHYDROUS [MI] \| sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate \| A14073 \| Q27236615 \| CCG-222119 \| J-008691 \| Sivelestat sodium anhydrous \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective leukocyte elastase inhibitor (IC50= 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigrationin vitro. Significantly attenuates ischemia-induced spinal cord injury, decre
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives
      - Level5 Benzamides
        Level6 Hippuric acids and derivatives
        Level7 Hippuric acids

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Benzamides - Hippuric acids and derivatives
Direct Parent	Hippuric acids
Alternative Parents	N-acyl-alpha amino acids Benzenesulfonamides Sulfanilides Phenol esters Benzenesulfonyl compounds Phenoxy compounds Benzoyl derivatives Organosulfonamides Dicarboxylic acids and derivatives Vinylogous amides Aminosulfonyl compounds Carboxylic acid salts Carboxylic acid esters Secondary carboxylic acid amides Carboxylic acids Organic oxides Organonitrogen compounds Hydrocarbon derivatives Carbonyl compounds Organic sodium salts Organic zwitterions
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Hippuric acid - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid or derivatives - Benzenesulfonamide - Sulfanilide - Phenol ester - Benzenesulfonyl group - Phenoxy compound - Benzoyl - Dicarboxylic acid or derivatives - Organosulfonic acid amide - Sulfonyl - Aminosulfonyl compound - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Vinylogous amide - Carboxamide group - Carboxylic acid ester - Carboxylic acid salt - Secondary carboxylic acid amide - Organic alkali metal salt - Carboxylic acid - Carboxylic acid derivative - Organonitrogen compound - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organooxygen compound - Organosulfur compound - Organic zwitterion - Organic oxide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as hippuric acids. These are compounds containing hippuric acid, which consists of a of a benzoyl group linked to the N-terminal of a glycine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ELANE Tclin Neutrophil elastase (3 Activities)

Discover Target: ELANE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Leukocyte elastase (8173 Activities)

Discover Target: ELANE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504769500
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769500
IUPAC Name	sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
INCHI	InChI=1S/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1
InChIKey	ZAIFANJZUGNYCK-UHFFFAOYSA-M
Smiles	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
Isomeric SMILES	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
PubChem CID	23664980
Molecular Weight	456.44

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
C2218309	Certificate of Analysis	Jan 15, 2025	S287743
C2218311	Certificate of Analysis	Jan 15, 2025	S287743
C2218307	Certificate of Analysis	Jan 15, 2025	S287743
C2218310	Certificate of Analysis	Jan 15, 2025	S287743
C2218308	Certificate of Analysis	Jan 15, 2025	S287743

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 22.82, Max Conc. mM: 50
Molecular Weight	456.400 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	456.097 Da
Monoisotopic Mass	456.097 Da
Topological Polar Surface Area	150.000 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	738.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hao-Dong Yang, Zhi-Shu Tang, Tao-Tao Xue, Huai-Li Xu, Bao-Long Hou, Ya-Ya Zhu, Zeng-Hu Su, Hong-Bo Xu. (2023) Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro. PHYTOCHEMISTRY, 215 (113851).
2. Hao-Dong Yang, Yuan-Gui Yang, Zhi-Shu Tang, Kang Ma, Hong-Bo Xu. (2024) Identification of lignans as selective cyclooxygenase-2 inhibitors from the extract of Acanthopanacis cortex. PHYTOCHEMISTRY, 226 (114208).

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