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Setrusumab (anti-Sclerostin) - Primary antibody, specific to SOST, Human IgG2SA, INHIBITOR of Sclerostin inhibitor, INHIBITOR of Sclerostin inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG2SA
  • Conjugation: Unconjugated
In stock
Item Number
Ab182819
Grouped product items
SKU Size
Availability
Price Qty
Ab182819-100μg
100μg
10
$109.90
Ab182819-1mg
1mg
4
$519.90
Ab182819-5mg
5mg
1
$1,399.90
Ab182819-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Setrusumab (anti-Sclerostin) - Primary antibody, specific to SOST, Human IgG2SA, INHIBITOR of Sclerostin inhibitor
Synonyms BEER antibody | CDD antibody | Cortical hyperostosis with syndactyly antibody | Sclerosteosis antibody | Sclerostin antibody | Sost antibody | SOST_HUMAN antibody | SOST1 antibody | UNQ2976/PRO7455/PRO7476 antibody | VBCH antibody | SOST | sclerostin | VB
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity SOST
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Sclerostin inhibitor
Product Description

Setrusumab (anti-Sclerostin) is a fully humanized monoclonal antibody targets sclerostin. Setrusumab (anti-Sclerostin) efftively improves bone strength. Setrusumab (anti-Sclerostin) can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG2SA
Light Chain Type lambdaC2
SDS-PAGE 143.44 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1847394-95-9

Associated Targets(Human)

SOST Tclin Sclerostin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Setrusumab (anti-Sclerostin) (Ab182819) - ELISA
Immobilized cyno-Sclerostin-ECD-his at 2.0 μg/mL can bind Setrusumab (anti-Sclerostin) (Ab182819) with the EC50 of 66.97 ng/mL.

Setrusumab (anti-Sclerostin) (Ab182819) - SEC
The purity of Setrusumab (anti-Sclerostin) (Ab182819) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0606948 Certificate of Analysis Jun 18, 2024 Ab182819
ZJ24F0606947 Certificate of Analysis Jun 18, 2024 Ab182819
ZJ24F0606949 Certificate of Analysis Jun 18, 2024 Ab182819

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