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setmelanotide, Melanocortin receptor 4 agonist, CAS No.rp174973, Melanocortin receptor 4 agonist

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Item Number
rp174973
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rp174973-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp174973-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name setmelanotide, Melanocortin receptor 4 agonist, CAS No.rp174973
Synonyms 1504602-49-6 | Setmelanotide | Setmelanotide [USAN:INN] | EX-A5542 | SETMELANOTIDE [WHO-DD] | Setmelanotide [USAN] | Setmelanotide acetate | RM-493 | AT23144 | BIM-22493 | (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentan
Grade Moligand™
Specifications & Purity Moligand™
Action Type AGONIST
Mechanism of action Melanocortin receptor 4 agonist

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Oligopeptides
Alternative Parents Cyclic peptides  N-acyl-alpha amino acids and derivatives  Macrolactams  Alpha amino acid amides  3-alkylindoles  Substituted pyrroles  Benzene and substituted derivatives  N-acyl amines  Acetamides  Heteroaromatic compounds  Imidazoles  Secondary carboxylic acid amides  Primary carboxylic acid amides  Organic disulfides  Guanidines  Lactams  Carboximidamides  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Carbonyl compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Alpha-oligopeptide - Cyclic alpha peptide - Macrolactam - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 3-alkylindole - Indole or derivatives - Indole - Fatty amide - Benzenoid - Monocyclic benzene moiety - Fatty acyl - Substituted pyrrole - N-acyl-amine - Acetamide - Azole - Pyrrole - Imidazole - Heteroaromatic compound - Organic disulfide - Lactam - Primary carboxylic acid amide - Secondary carboxylic acid amide - Carboxamide group - Guanidine - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Not available

Associated Targets(Human)

MC5R Tchem Melanocortin receptor 5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC4R Tclin Melanocortin receptor 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC3R Tchem Melanocortin receptor 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MC3R Tchem Melanocortin receptor 3 (5659 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MC5R Tchem Melanocortin receptor 5 (4283 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MC1R Tclin Melanocortin receptor 1 (2696 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mc4r Melanocortin receptor 4 (1205 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Storage and Shipping

CAS rp174973

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names 1504602-49-6 | Setmelanotide | Setmelanotide [USAN:INN] | EX-A5542 | SETMELANOTIDE [WHO-DD] | Setmelanotide [USAN] | Setmelanotide acetate | RM-493 | AT23144 | BIM-22493 | (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentan
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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