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SET 2 - ≥98%(HPLC), high purity , CAS No.2313525-20-9, Channel blocker of TRPV2

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 2313525-20-9
Molecular Weight: 402.44
PubChem CID: 155541857
PubChem SID: 488203091

In stock

Item Number

S287626

Grouped product items
SKU	Size	Availability	Price
S287626-5mg	5mg	3	$107.90
S287626-10mg	10mg	1	$177.90
S287626-25mg	25mg	1	$375.90
S287626-50mg	50mg	1	$632.90
S287626-100mg	100mg	1	$1,038.90

Selective TRPV2 antagonist

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181) TRPV2 Channel blocker (3)

Basic Description

Synonyms	TRPV2 antagonist SET2 \| N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide \| AKOS040755628 \| HY-132222 \| DTXSID101336558 \| GTPL12547 \| 2313525-20-9 \| N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50= 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migrationin vitro.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPV2

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organosulfur compounds
  - Class Thioethers
    - Subclass Aryl thioethers

Kingdom	Organic compounds
Superclass	Organosulfur compounds
Class	Thioethers
Subclass	Aryl thioethers
Intermediate Tree Nodes	Not available
Direct Parent	Aryl thioethers
Alternative Parents	Dialkylarylamines Aminopyrimidines and derivatives Alkylarylthioethers Imidolactams Heteroaromatic compounds Furans Amino acids and derivatives Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Carboxylic acid amides Carboximidamides Azacyclic compounds Amidines Organopnictogen compounds Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Aryl thioether - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Alkylarylthioether - Aminopyrimidine - Imidolactam - Pyrimidine - Heteroaromatic compound - Furan - Tertiary amine - Carboxamide group - Amino acid or derivatives - Oxacycle - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Sulfenyl compound - Carboximidamide - Carboxylic acid derivative - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as aryl thioethers. These are organosulfur compounds containing a thioether group that is substituted by an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 (0 Activities)

Discover Target: TRPV2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

Discover Target: TRPV3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv1 Transient receptor potential cation channel subfamily V member 1 (45 Activities)

Discover Target: Trpv1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488203091
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488203091
IUPAC Name	N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
INCHI	InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)
InChIKey	LZHSWRWIMQRTOP-UHFFFAOYSA-N
Smiles	CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
Isomeric SMILES	CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
PubChem CID	155541857
Molecular Weight	402.44

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D2307858	Certificate of Analysis	Feb 20, 2023	S287626
D2307773	Certificate of Analysis	Feb 20, 2023	S287626
D2307869	Certificate of Analysis	Feb 20, 2023	S287626
D2307779	Certificate of Analysis	Feb 20, 2023	S287626
D2307870	Certificate of Analysis	Feb 20, 2023	S287626
D2307868	Certificate of Analysis	Feb 20, 2023	S287626
D2307772	Certificate of Analysis	Feb 20, 2023	S287626
D2307874	Certificate of Analysis	Feb 20, 2023	S287626
D2307780	Certificate of Analysis	Feb 20, 2023	S287626
D2307857	Certificate of Analysis	Feb 20, 2023	S287626

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 40.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.12, Max Conc. mM: 50

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