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Selumetinib sulfate - 99%, high purity , Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor, CAS No.943332-08-9, Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor

COA

Grade & Purity:

≥99%

Cas Number: 943332-08-9
Molecular Weight: 555.76
EC Number: 642-432-8
PubChem CID: 16214875

In stock

Item Number

S650561

Grouped product items
SKU	Size	Availability	Price
S650561-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
S650561-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
S650561-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
S650561-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$599.90

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Apoptosis (4276) MAPK/ERK (1) MAPK/ERK Pathway (546) MEK (59) Pathway Apoptosis (1)

Basic Description

Synonyms	5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzimidazole-6-Carboxamide Sulfate \| 5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzimidazole-6-Carboxamide Sulphate \| MS-30133 \| HY-50706A \| Kosel
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC 50 of 14 nM for MEK1 . Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
Product Description	Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC 50 of 14 nM for MEK1 . Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. In Vitro Selumetinib (AZD6244) causes a time- and dose-dependent reduction in DNA synthesis and cell viability in primary, induces growth arrest and apoptosis associated with the inactivation of ERK in primary 2-1318 cells. Selumetinib (AZD6244) (1µM) shows anti-proliferative effects through G0/G1 arrest on H-441, H-1437 cells. Selumetinib (AZD6244) results in the growth inhibition of several cell lines containing B-Raf and Ras mutations but has no effect on a normal fibroblast cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Selumetinib (AZD6244, 50 and 100 mg/kg, p.o.) decreases the growth rate of 4-1318 xenografts in a dose-dependent manner; AZD6244 when given at the dose of 50 mg/kg also significantly suppresses the growth of the 5-1318, 2-1318, 26-1004, and 29-1104 xenografts . Selumetinib (ARRY-142886, 10, 25, 50, or 100 mg/kg, p.o.) is capable of inhibiting both ERK1/2 phosphorylation and growth of HT-29 xenograft tumors in nude mice. Tumor regressions are also seen in a BxPC3 xenograft model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives
      - Level5 Halobenzoic acids and derivatives
        Level6 3-halobenzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Halobenzoic acids and derivatives
Direct Parent	3-halobenzoic acids and derivatives
Alternative Parents	Benzimidazoles Aniline and substituted anilines Chlorobenzenes Bromobenzenes Primary aromatic amines Aryl bromides Aryl chlorides Organic sulfuric acids Aryl fluorides N-substituted imidazoles Vinylogous amides Heteroaromatic compounds Amino acids and derivatives Secondary amines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organobromides Organochlorides Organofluorides Primary alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	3-halobenzoic acid or derivatives - Benzimidazole - Aniline or substituted anilines - Bromobenzene - Chlorobenzene - Halobenzene - Sulfuric acid - Aryl bromide - Aryl chloride - Aryl fluoride - Aryl halide - N-substituted imidazole - Primary aromatic amine - Vinylogous amide - Azole - Heteroaromatic compound - Imidazole - Organic sulfuric acid or derivatives - Amino acid or derivatives - Azacycle - Secondary amine - Organoheterocyclic compound - Carboxylic acid derivative - Organobromide - Organofluoride - Hydrocarbon derivative - Organochloride - Organic oxide - Alcohol - Organonitrogen compound - Organic oxygen compound - Primary alcohol - Amine - Organohalogen compound - Organic nitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 3-halobenzoic acids and derivatives. These are benzoic acids or derivatives carrying a halogen atom at the 3-position of the benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide;sulfuric acid
INCHI	InChI=1S/C17H15BrClFN4O3.H2O4S/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19;1-5(2,3)4/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26);(H2,1,2,3,4)
InChIKey	GRKFGZYYYYISDX-UHFFFAOYSA-N
Smiles	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO.OS(=O)(=O)O
Isomeric SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO.OS(=O)(=O)O
Alternate CAS	943332-08-9
PubChem CID	16214875
NSC Number	748727
Molecular Weight	555.76

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
J2422776	Certificate of Analysis	Jul 24, 2024	S650561
J2422777	Certificate of Analysis	Jul 24, 2024	S650561
J2422778	Certificate of Analysis	Jul 24, 2024	S650561
J2422782	Certificate of Analysis	Jul 24, 2024	S650561
J2422786	Certificate of Analysis	Jul 24, 2024	S650561
J2422781	Certificate of Analysis	Jul 24, 2024	S650561

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (89.97 mM; Need ultrasonic) H2O : 1 mg/mL (1.80 mM; Need ultrasonic)
Sensitivity	Moisture sensitive
Molecular Weight	555.800 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	553.967 Da
Monoisotopic Mass	553.967 Da
Topological Polar Surface Area	171.000 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	604.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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