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SC144 - 98%, high purity , CAS No.895158-95-9

COA

Grade & Purity:

≥98%

Cas Number: 895158-95-9
Molecular Weight: 322.3
PubChem CID: 400169
PubChem SID: 504758634

In stock

Item Number

S129564

Grouped product items
SKU	Size	Availability	Price
S129564-1mg	1mg	3	$11.90
S129564-5mg	5mg	3	$48.90
S129564-10mg	10mg	3	$83.90
S129564-25mg	25mg	2	$167.90
S129564-50mg	50mg	2	$281.90
S129564-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$479.90

View related series

Immunology/Inflammation (1929) Interleukin Related (129)

Basic Description

Synonyms	N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide \| 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid \| 2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	SC144 is a potent inhibitor of glycoprotein 130 (gp130). SC144 binds to gp130 and blocks STAT3 phosphorylation, nuclear translocation and expression of STAT3 responsive genes. SC144 inhibits the growth of several tumor cell lines, independent of p53 or ho
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SC144 hydrochloride has been used: as a glycoprotein 130 (gp130) inhibitor to evaluate the effect of bazedoxifene on interleukin (IL-6) mediated cell viability in pancreatic cancer cells as a gp130 inhibitor to study its effects on signal transducer and activator of transcription 3 (STAT3) activation in mesenchymal precursor cells (KMM) cells as an interleukin 6 signal transducer (IL-6ST) inhibitor in media to test its ability to block serum-induced migration/invasion

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines
      - Level5 Quinoxalines
        Level6 Pyrroloquinoxalines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Quinoxalines
Direct Parent	Pyrroloquinoxalines
Alternative Parents	Pyrrolopyrazines Pyrazinecarboxamides Imidolactams Benzenoids Aryl fluorides Pyrroles Heteroaromatic compounds Carboxylic acid hydrazides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyrroloquinoxaline - Pyrazine carboxylic acid or derivatives - Pyrazinecarboxamide - Pyrrolopyrazine - Aryl fluoride - Aryl halide - Pyrazine - Imidolactam - Benzenoid - Pyrrole - Heteroaromatic compound - Carboxylic acid hydrazide - Carboxylic acid derivative - Azacycle - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyrroloquinoxalines. These are organic heterocyclic compounds containing a pyrrole ring fused to a quinoxaline ring system.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HT-29 (80576 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

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LNCaP (8286 Activities)

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MDA-MB-435 (38290 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504758634
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758634
IUPAC Name	N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide
INCHI	InChI=1S/C16H11FN6O/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12/h1-9H,(H,20,21)(H,22,24)
InChIKey	UEADAWQSJOWXBK-UHFFFAOYSA-N
Smiles	C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4
Isomeric SMILES	C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4
PubChem CID	400169
Molecular Weight	322.3

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
A2211738	Certificate of Analysis	Oct 12, 2023	S129564
A2211838	Certificate of Analysis	Oct 12, 2023	S129564
A2211831	Certificate of Analysis	Oct 12, 2023	S129564
A2211586	Certificate of Analysis	Oct 12, 2023	S129564
A2211560	Certificate of Analysis	Oct 12, 2023	S129564
A2211585	Certificate of Analysis	Oct 12, 2023	S129564

Chemical and Physical Properties

Solubility	DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight	322.300 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	322.098 Da
Monoisotopic Mass	322.098 Da
Topological Polar Surface Area	84.200 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	466.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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SC144 - 98%, high purity , CAS No.895158-95-9

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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