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Apoptosis
Apoptosis
SC-1 - 98%, high purity , CAS No.1313019-65-6

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SC-1 - 98%, high purity , CAS No.1313019-65-6

COA

Grade & Purity:

≥98%

Cas Number: 1313019-65-6
Molecular Weight: 431.80
PubChem CID: 53327725

In stock

Item Number

S412668

Grouped product items
SKU	Size	Availability	Price
S412668-1mg	1mg	3	$46.90
S412668-5mg	5mg	3	$139.90
S412668-10mg	10mg	3	$224.90
S412668-50mg	50mg	1	$719.90
S412668-25mg	25mg	2	$449.90
S412668-100mg	100mg	1	$999.90

View related series

Apoptosis (4276) JAK/STAT Signaling (507) STAT (139) STAT inhibitor (1) Stem Cell/Wnt (1019)

Basic Description

Synonyms	1313019-65-6 \| E73479 \| SCHEMBL15746582 \| 3-[4-chloro-3-(trifluoromethyl)phenyl]-1-[4-(4-cyanophenoxy)phenyl]urea \| 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea \| AKOS032470290 \| 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-(4-cy
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	SC-1 blocks STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines. SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information SC-1 blocks STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines. SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Diphenylethers

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Diphenylethers
Intermediate Tree Nodes	Not available
Direct Parent	Diphenylethers
Alternative Parents	Diarylethers Trifluoromethylbenzenes N-phenylureas Benzonitriles Phenoxy compounds Phenol ethers Chlorobenzenes Aryl chlorides Ureas Nitriles Organochlorides Hydrocarbon derivatives Organofluorides Alkyl fluorides Carbonyl compounds Organic oxides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Diphenylether - Diaryl ether - Trifluoromethylbenzene - N-phenylurea - Phenoxy compound - Benzonitrile - Phenol ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Urea - Ether - Carbonitrile - Nitrile - Alkyl fluoride - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Carbonyl group - Cyanide - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

Discover Target: RAF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)

Discover Target: PTPN6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-(4-cyanophenoxy)phenyl]urea
INCHI	InChI=1S/C21H13ClF3N3O2/c22-19-10-5-15(11-18(19)21(23,24)25)28-20(29)27-14-3-8-17(9-4-14)30-16-6-1-13(12-26)2-7-16/h1-11H,(H2,27,28,29)
InChIKey	HVPZDXDXIQZKHU-UHFFFAOYSA-N
Smiles	C1=CC(=CC=C1C#N)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Isomeric SMILES	C1=CC(=CC=C1C#N)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
WGK Germany	3
PubChem CID	53327725
Molecular Weight	431.80

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
F2417438	Certificate of Analysis	Mar 06, 2024	S412668
F2417439	Certificate of Analysis	Mar 06, 2024	S412668
F2417453	Certificate of Analysis	Mar 06, 2024	S412668
F2417454	Certificate of Analysis	Mar 06, 2024	S412668
F2417455	Certificate of Analysis	Mar 06, 2024	S412668
F2417458	Certificate of Analysis	Mar 06, 2024	S412668
F2417460	Certificate of Analysis	Mar 06, 2024	S412668
F2417490	Certificate of Analysis	Mar 06, 2024	S412668
F2417491	Certificate of Analysis	Mar 06, 2024	S412668
F2417456	Certificate of Analysis	Mar 06, 2024	S412668
F2417489	Certificate of Analysis	Mar 06, 2024	S412668
F2417459	Certificate of Analysis	Mar 06, 2024	S412668

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Chemical and Physical Properties

Molecular Weight	431.800 g/mol
XLogP3	6.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	431.065 Da
Monoisotopic Mass	431.065 Da
Topological Polar Surface Area	74.200 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	623.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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