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SB-3CT - ≥98%, high purity , CAS No.292605-14-2, Inhibitor of MMP2;Inhibitor of MMP9

1 Citations

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 292605-14-2
Molecular Weight: 306.4
PubChem CID: 9883002
PubChem SID: 504765039

In stock

Item Number

S275790

Grouped product items
SKU	Size	Availability	Price
S275790-1mg	1mg	2	$28.90
S275790-5mg	5mg	2	$116.90
S275790-25mg	25mg	2	$303.90
S275790-50mg	50mg	2	$489.90
S275790-100mg	100mg	2	$882.90

Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor

View related series

Amino Acid/Protein Metabolism (1836) Metabolic Enzyme/Protease (4860) MMP (148) MMP2 Inhibitor (10) MMP9 Inhibitor (11)

Basic Description

Synonyms	CCG-267539 \| SCHEMBL2684163 \| Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]- \| NCGC00024565-02 \| AC-32656 \| DTXSID70432359 \| 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane \| MFCD09836266 \| AS-67674 \| STK980475 \| 2-[(4-PHENOXYBENZENESULFONYL)METHYL]THIIRANE
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (K i values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (K i values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM).
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MMP2;Inhibitor of MMP9
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Diphenylethers

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Diphenylethers
Intermediate Tree Nodes	Not available
Direct Parent	Diphenylethers
Alternative Parents	Diarylethers Benzenesulfonyl compounds Phenoxy compounds Phenol ethers Sulfones Thiiranes Dialkylthioethers Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Diphenylether - Diaryl ether - Benzenesulfonyl group - Phenoxy compound - Phenol ether - Sulfone - Sulfonyl - Ether - Organoheterocyclic compound - Thiirane - Thioether - Dialkylthioether - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organosulfur compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MMP14 Tchem Matrix metalloproteinase-14 (2 Activities)

Discover Target: MMP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 (6 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (6 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

Discover Target: MMP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)

Discover Target: MMP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Adam17 ADAM17 (14 Activities)

Discover Target: Adam17

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504765039
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504765039
IUPAC Name	2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane
INCHI	InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
InChIKey	LSONWRHLFZYHIN-UHFFFAOYSA-N
Smiles	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3
Isomeric SMILES	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3
PubChem CID	9883002
Molecular Weight	306.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
L2420132	Certificate of Analysis	Dec 30, 2024	S275790
I2202895	Certificate of Analysis	Jun 13, 2023	S275790
I2202896	Certificate of Analysis	Jun 13, 2023	S275790
I2202897	Certificate of Analysis	Jun 13, 2023	S275790
I2202719	Certificate of Analysis	Jun 13, 2023	S275790
I2202718	Certificate of Analysis	Jun 13, 2023	S275790

Chemical and Physical Properties

Solubility	Soluble in DMSO to 25 mM and ethanol
Sensitivity	Heat sensitive
Melt Point(°C)	101 °C
Molecular Weight	306.400 g/mol
XLogP3	3.200
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	306.038 Da
Monoisotopic Mass	306.038 Da
Topological Polar Surface Area	77.100 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	401.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA. (2025) Effect of electroacupuncture on MMP-2/9 pathway mediated the blood-brain barrier permeability in mice with Parkinson's disease. World Journal of Acupuncture-Moxibustion,

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