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SB 225002 - 98%, high purity , CAS No.182498-32-4, Antagonist of CXCR2

COA COA
In stock
Item Number
S275393
Grouped product items
SKU Size
Availability
 Price Qty
S275393-5mg
5mg
5
$53.90
S275393-10mg
10mg
3
$75.90
S275393-50mg
50mg
2
$314.90
S275393-100mg
100mg
1
$532.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

A selective non-peptide CXCR2 antagonist

View related series
Class A GPCR (4138) CXCR (81) CXCR2 Antagonist (8) GPCR/G Protein (3172) Immunology/Inflammation (1929)

Basic Description

Synonyms L000539 | J-011676 | CS-3538 | Q27088712 | SCHEMBL1110610 | NCGC00167841-01 | BRD-K61323504-001-03-2 | N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea | HMS3648O06 | CCG-268049 | HY-16711 | BDBM50203012 | BCP11852 | HSCI1_000088 | DTXSID20397383 | 1-(2
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms A selective non-peptide CXCR2 antagonist. Inhibits IL-8 binding to CXCR2 (IC 50 = 22 nM).
Source Synthetic
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of CXCR2
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Describtion:

SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Phenols
Subclass Nitrophenols
Intermediate Tree Nodes Not available
Direct Parent Nitrophenols
Alternative Parents N-phenylureas  Nitrobenzenes  Nitroaromatic compounds  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Bromobenzenes  Aryl bromides  Ureas  Propargyl-type 1,3-dipolar organic compounds  Organic oxoazanium compounds  Hydrocarbon derivatives  Carbonyl compounds  Organic oxides  Organobromides  Organonitrogen compounds  Organopnictogen compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Nitrophenol - N-phenylurea - Nitrobenzene - Nitroaromatic compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Carbonic acid derivative - Organic nitro compound - C-nitro compound - Urea - Organic oxoazanium - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Allyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as nitrophenols. These are compounds containing a nitrophenol moiety, which consists of a benzene ring bearing both a hydroxyl group and a nitro group on two different ring carbon atoms.
External Descriptors Not available

Associated Targets(Human)

CXCR2 Tchem C-X-C chemokine receptor type 2 (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CXCR1 Tchem C-X-C chemokine receptor type 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CXCR2 Tchem Interleukin-8 receptor B (3491 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CXCR1 Tchem Interleukin-8 receptor A (2256 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488194611
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488194611
IUPAC Name 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
INCHI InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChIKey MQBZVUNNWUIPMK-UHFFFAOYSA-N
Smiles C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
Isomeric SMILES C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
PubChem CID 3854666
Molecular Weight 352.14

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
D23201095 Certificate of Analysis Feb 17, 2025 S275393
D23201089 Certificate of Analysis Feb 23, 2024 S275393
D23201093 Certificate of Analysis Feb 23, 2024 S275393
D23201094 Certificate of Analysis Feb 23, 2024 S275393
D23201088 Certificate of Analysis Feb 23, 2024 S275393
D23201092 Certificate of Analysis Jan 31, 2024 S275393
D23201097 Certificate of Analysis Jan 31, 2024 S275393
D23201104 Certificate of Analysis Jan 31, 2024 S275393

Chemical and Physical Properties

Solubility Soluble in DMSO to 75 mM and in ethanol to 25 mM
Molecular Weight 352.140 g/mol
XLogP3 2.600
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 350.985 Da
Monoisotopic Mass 350.985 Da
Topological Polar Surface Area 107.000 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 390.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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