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SB 200646 - 98%, high purity , CAS No.143797-63-1

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S412790
Grouped product items
SKU Size
Availability
 Price Qty
S412790-5mg
5mg
3
$446.90
S412790-10mg
10mg
3
$686.90
S412790-25mg
25mg
3
$1,373.90
S412790-50mg
50mg
3
$2,163.90
S412790-100mg
100mg
3
$3,433.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

5-HT2 Selective Inhibitors | Agonists | Antagonists | Modulators

View related series
Class A GPCR (4138)

Basic Description

Synonyms HY-103129A | 1-(1-methylindol-5-yl)-3-(3-pyridyl)urea | UNII-RT8F72CL8L | CS-0119679 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea | N-(1-METHYL-1H-INDOL-5-YL)-N-3-PYRIDINYLUREA | Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl- | SCHEMBL173735 | SB 200
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Information

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of5-HT2B/2Cover 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.


Targets

5-HT2B (rat) (Cell-free assay); 5-HT2C (Rat) (Cell-free assay); 5-HT2A (rat) (Cell-free assay) 7.5(pKi); 6.9(pKi); 5.2(pKi)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass N-alkylindoles
Intermediate Tree Nodes Not available
Direct Parent N-alkylindoles
Alternative Parents Indoles  Pyridines and derivatives  N-methylpyrroles  Benzenoids  Heteroaromatic compounds  Isoureas  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents N-alkylindole - Indole - N-methylpyrrole - Benzenoid - Substituted pyrrole - Pyridine - Heteroaromatic compound - Pyrrole - Isourea - Carboximidic acid derivative - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
External Descriptors indoles

Product Properties

ALogP 1.871
HBD Count 2
Rotatable Bond 2

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2B Tclin 5-hydroxytryptamine receptor 2B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr2b Serotonin receptor 2a and 2b (5HT2A and 5HT2B) (71 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504756978
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504756978
IUPAC Name 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea
INCHI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
InChIKey OJZZJTLBYXHUSJ-UHFFFAOYSA-N
Smiles CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3
Isomeric SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3
PubChem CID 126769
Molecular Weight 266.3

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
L2418261 Certificate of Analysis Dec 27, 2024 S412790
K2225651 Certificate of Analysis Sep 19, 2024 S412790
K2225657 Certificate of Analysis Sep 19, 2024 S412790
K2225655 Certificate of Analysis Sep 19, 2024 S412790
K2225656 Certificate of Analysis Sep 19, 2024 S412790
K2225659 Certificate of Analysis Sep 19, 2024 S412790

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 53 mg/mL (199.02 mM); Ethanol: 2 mg/mL (7.51 mM); Water: ˂1 mg/mL
DMSO(mg / mL) Max Solubility 53
DMSO(mM) Max Solubility 199.023657529103
Water(mg / mL) Max Solubility ˂1
Molecular Weight 266.300 g/mol
XLogP3 1.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 2
Exact Mass 266.117 Da
Monoisotopic Mass 266.117 Da
Topological Polar Surface Area 59.000 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 349.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. SB 200646
    SB 200646
    • 10mM in DMSO

    Starting at $241.90

  2. SB 200646 hydrochloride
    SB 200646 hydrochloride
    • ≥96%

    Starting at $71.90

Solution Calculators

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