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Sapropterin dihydrochloride - 10mM in DMSO, high purity , CAS No.69056-38-8, Phenylalanine-4-hydroxylase activator

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Sapropterin dihydrochloride - 10mM in DMSO, high purity , CAS No.69056-38-8, Phenylalanine-4-hydroxylase activator

COA

Grade & Purity:

10mM in DMSO

Cas Number: 69056-38-8
Molecular Weight: 314.17
PubChem CID: 135409471

In stock

Item Number

S425540

Grouped product items
SKU	Size	Availability	Price	Qty
S425540-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$172.90

View related series

Compound libraries (12325)

Basic Description

Synonyms	Sapropterin dihydrochloride \| 69056-38-8 \| Biopten \| SAPROPTERIN HYDROCHLORIDE \| Sapropterin HCl \| Kuvan \| (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride \| Phenoptin \| BioMarin T 1401 \| Shiratori SN 0588 \| Dapropterin hydroch
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	ACTIVATOR
Mechanism of action	Phenylalanine-4-hydroxylase activator
Product Description	Product description Sapropterin ((6R)-BH4) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) Product application (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH4 has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pteridines and derivatives
    - Subclass Pterins and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pteridines and derivatives
Subclass	Pterins and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biopterins and derivatives
Alternative Parents	Secondary alkylarylamines Pyrimidones Aminopyrimidines and derivatives Vinylogous amides Heteroaromatic compounds 1,3-aminoalcohols Secondary alcohols 1,2-diols 1,2-aminoalcohols Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Biopterin - Aminopyrimidine - Pyrimidone - Secondary aliphatic/aromatic amine - Pyrimidine - 1,3-aminoalcohol - Heteroaromatic compound - Vinylogous amide - 1,2-aminoalcohol - 1,2-diol - Secondary alcohol - Azacycle - Secondary amine - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Amine - Alcohol - Organopnictogen compound - Hydrochloride - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.
External Descriptors	hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
INCHI	InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChIKey	RKSUYBCOVNCALL-NTVURLEBSA-N
Smiles	CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O.Cl.Cl
Isomeric SMILES	C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)NC(=N2)N)O)O.Cl.Cl
PubChem CID	135409471
Molecular Weight	314.17

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	314.170 g/mol
XLogP3
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	313.071 Da
Monoisotopic Mass	313.071 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	405.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

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