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Santacruzamate A - ≥98%(HPLC), high purity , CAS No.1477949-42-0, Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6

COA COA
In stock
Item Number
S288868
Grouped product items
SKU Size
Availability
 Price Qty
S288868-10mg
10mg
3
$63.90
S288868-50mg
50mg
3
$246.90
S288868-100mg
100mg
2
$370.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Highly potent and selective HDAC2 inhibitor

View related series
Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) HDAC (160) histone deacetylase 2 Inhibitor (23) histone deacetylase 4 Inhibitor (12) histone deacetylase 6 Inhibitor (33) Histone Modification (1379)

Basic Description

Synonyms ethyl N-{3-[(2-phenylethyl)carbamoyl]propyl}carbamate | HY-N0931 | santacruzamate A | GTPL7916 | NCGC00386359-03 | AKOS026750400 | J-690192 | CHEBI:188612 | N-[4-oxo-4-[(2-Phenylethyl)amino]butyl]-carbamic acid ethyl ester | AS-49855 | EX-A910 | Tox21_202
Specifications & Purity Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms Highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50= 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC50= 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50>1 μM for HDAC
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives
Direct Parent Gamma amino acids and derivatives
Alternative Parents N-acyl amines  Benzene and substituted derivatives  Carbamate esters  Secondary carboxylic acid amides  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Gamma amino acid or derivatives - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Benzenoid - Fatty acyl - Carbamic acid ester - Secondary carboxylic acid amide - Carboxamide group - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
External Descriptors Not available

Associated Targets(Human)

HDAC4 Tclin Histone deacetylase 4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC2 Tclin Histone deacetylase 2 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (978 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC8 Tclin Histone deacetylase 8 (4516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC10 Tclin Histone deacetylase 10 (801 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC2 Tclin Histone deacetylase 2 (3971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC9 Tclin Histone deacetylase 9 (708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC11 Tclin Histone deacetylase 11 (967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC7 Tclin Histone deacetylase 7 (1047 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HuT78 (515 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT3 Tchem NAD-dependent deacetylase sirtuin 3 (1285 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT1 Tchem NAD-dependent deacetylase sirtuin 1 (3505 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC3 Tclin Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (735 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT5 Tchem NAD-dependent protein deacylase sirtuin-5, mitochondrial (1056 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DNMT3A Tclin DNMT3A2/3L complex (48 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DNMT3B Tchem DNMT3B-DNMT3L complex (25 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac5 Histone deacetylase 5 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Schistosoma mansoni (6170 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772307
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772307
IUPAC Name ethyl N-[4-oxo-4-(2-phenylethylamino)butyl]carbamate
INCHI InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
InChIKey HTOYBIILVCHURC-UHFFFAOYSA-N
Smiles CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1
Isomeric SMILES CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1
PubChem CID 72946782
Molecular Weight 278.35

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
I2216327 Certificate of Analysis Jun 10, 2025 S288868
I2216415 Certificate of Analysis Jun 10, 2025 S288868
I2216648 Certificate of Analysis Jun 10, 2025 S288868

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 27.84, Max Conc. mM: 100
Molecular Weight 278.350 g/mol
XLogP3 1.900
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 9
Exact Mass 278.163 Da
Monoisotopic Mass 278.163 Da
Topological Polar Surface Area 67.400 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 289.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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