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Samuraciclib hydrochloride hydrate - 10mM in DMSO, high purity , CAS No.S661650(DMSO)

COA

Grade & Purity:

10mM in DMSO

Molecular Weight: 552.33

In stock

Item Number

S661650

Grouped product items
SKU	Size	Availability	Price	Qty
S661650-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$365.90

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Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1 , CDK2 (IC 50 of 578 IC50& Target:CDK7/CycH/MAT1\|41 nM (IC\|50\|)\|CDK2/cycE1\|578 nM (IC\|50\|)\|CDK1\|1.8 μM (IC\|50\|)\|CDK4\|49 μM (IC\|50\|)\|CDK5\|9.4 μM (IC\|50\|)\|CDK6\|34 μM (IC\|50\|)\|CDK9\|1.2 μM (IC\|50\|) In Vitro:Samuraciclib (ICEC0942; 0-10 µM; 24 hours; HCT116 cells) hydrochloride hydrate treatment promotes cell apoptosis. Samuraciclib (ICEC0942; 0-10 µM; 24 hours; HCT116 cells) hydrochloride hydrate treatment induces cell cycle arrest. Samuraciclib (I In Vivo:Samuraciclib (ICEC0942; 100mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) hydrochloride hydrate treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 p Biological Activity:Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1 , CDK2 (IC 50 of 578

Names and Identifiers

Smiles	O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2.Cl.O.[2.5].[3.7]
Molecular Weight	552.33

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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