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Salicylidene salicylhydrazide (SCS) - 97%, high purity , CAS No.3232-36-8

1 Citations COA COA
In stock
Item Number
S287391
Grouped product items
SKU Size
Availability
 Price Qty
S287391-1g
1g
3
$26.90
S287391-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
S287391-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$359.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent GABAAantagonist; β1-subunit selective

View related series
GABA Receptor (181) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320)

Basic Description

Synonyms N-Salicylidene-N'-salicyloylhydrazine | N-Salicylidene-N-salicyloylhydrazine | SR-01000872611-3 | SALICYLIDENESALICYLHYDRAZIDE | 2-Hydroxy-N'-[(E)-(2-hydroxyphenyl)methylidene]benzohydrazide | 2-HYDROXY-N'~1~-[(2-HYDROXYPHENYL)METHYLENE]BENZOHYDRAZIDE | S
Specifications & Purity Moligand™, ≥97%
Biochemical and Physiological Mechanisms Potent and selective partial inhibitor ofβ1-containing GABAAreceptors (IC50values are 4.5, 5.3 and 7.9 nM atα2β1γ1θ,α2β1γ1 andα2β1γ2s GABAAreceptors respectively). May bind allosterically to a novel site on GABAAreceptor.
Storage Temp Room temperature
Shipped In Normal
Grade Moligand™

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Hydroxybenzoic acid derivatives - Salicylic acid and derivatives
Direct Parent Salicylamides
Alternative Parents Benzoyl derivatives  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Carboxylic acids and derivatives  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Salicylamide - Benzoyl - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as salicylamides. These are carboxamide derivatives of salicylic acid. Salicylic acid is the ortho-hydroxylated derivative of benzoic acid.
External Descriptors Not available

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nakaseomyces glabratus (9108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
J774 (3120 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504773333
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504773333
IUPAC Name 2-hydroxy-N-[(E)-(2-hydroxyphenyl)methylideneamino]benzamide
INCHI InChI=1S/C14H12N2O3/c17-12-7-3-1-5-10(12)9-15-16-14(19)11-6-2-4-8-13(11)18/h1-9,17-18H,(H,16,19)/b15-9+
InChIKey OMCYEZUIYGPHDJ-OQLLNIDSSA-N
Smiles C1=CC=C(C(=C1)C=NNC(=O)C2=CC=CC=C2O)O
Isomeric SMILES C1=CC=C(C(=C1)/C=N/NC(=O)C2=CC=CC=C2O)O
PubChem CID 135445765
Molecular Weight 256.26

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
F2417483 Certificate of Analysis Feb 29, 2024 S287391
F2417484 Certificate of Analysis Feb 29, 2024 S287391
F2417485 Certificate of Analysis Feb 29, 2024 S287391
F2417486 Certificate of Analysis Feb 29, 2024 S287391
F2417487 Certificate of Analysis Feb 29, 2024 S287391
F2417488 Certificate of Analysis Feb 29, 2024 S287391

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 12.81, Max Conc. mM: 50
Molecular Weight 256.260 g/mol
XLogP3 2.700
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 3
Exact Mass 256.085 Da
Monoisotopic Mass 256.085 Da
Topological Polar Surface Area 81.900 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 333.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Cheng Li, Yang Tian, Jiahuan Pei, Yuyang Zhang, Daokuan Hao, Tianjiao Han, Xiaoqin Wang, Shuang Song, Linjuan Huang, Zhongfu Wang.  (2023)  Sea cucumber chondroitin sulfate polysaccharides attenuate OVA-induced food allergy in BALB/c mice associated with gut microbiota metabolism and Treg cell differentiation.  Food & Function,  14  (16): (7375-7386). 

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