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Salermide - ≥98%(HPLC), high purity , CAS No.1105698-15-4

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
S287227
Grouped product items
SKU Size
Availability
 Price Qty
S287227-5mg
5mg
2
$58.90
S287227-10mg
10mg
3
$82.90
S287227-25mg
25mg
3
$177.90
S287227-50mg
50mg
2
$307.90
S287227-100mg
100mg
2
$545.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

SIRT1 and SIRT2 inhibitor

View related series
Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) Histone Modification (1379) Sirtuin (94)

Basic Description

Synonyms BDBM50309827 | (E)-N-(3-((2-hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide | SCHEMBL8103931 | EX-A1238 | N-[3-[(2-oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide | N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.Salermide is a novel Sirtuin 1
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

application：

Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR. 

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Naphthalenes
Subclass Naphthols and derivatives
Intermediate Tree Nodes Not available
Direct Parent Naphthols and derivatives
Alternative Parents 1-hydroxy-2-unsubstituted benzenoids  Benzene and substituted derivatives  Shiff bases  Propargyl-type 1,3-dipolar organic compounds  Carboximidic acids  Organopnictogen compounds  Organooxygen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic homopolycyclic compounds
Substituents 2-naphthol - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Shiff base - Aldimine - Carboximidic acid - Carboximidic acid derivative - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Imine - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.
External Descriptors Not available

Associated Targets(Human)

MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RKO (1376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-937 (7138 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT3 Tchem NAD-dependent deacetylase sirtuin 3 (1285 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT1 Tchem NAD-dependent deacetylase sirtuin 1 (3505 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT6 Tchem NAD-dependent protein deacetylase sirtuin-6 (671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT5 Tchem NAD-dependent protein deacylase sirtuin-5, mitochondrial (1056 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Schistosoma mansoni (6170 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caenorhabditis elegans (1055 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504773410
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504773410
IUPAC Name N-[3-[(2-hydroxynaphthalen-1-yl)methylideneamino]phenyl]-2-phenylpropanamide
INCHI InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)
InChIKey HQSSEGBEYORUBY-UHFFFAOYSA-N
Smiles CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
Isomeric SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
PubChem CID 135659046
Molecular Weight 394.47

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
F2523293 Certificate of Analysis Jun 26, 2025 S287227
K2212740 Certificate of Analysis Jul 06, 2022 S287227
K2212741 Certificate of Analysis Jul 06, 2022 S287227
K2212707 Certificate of Analysis Jul 06, 2022 S287227
K2212708 Certificate of Analysis Jul 06, 2022 S287227
K2212668 Certificate of Analysis Jul 06, 2022 S287227

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 39.45, Max Conc. mM: 100
Sensitivity Moisture sensitive
Molecular Weight 394.500 g/mol
XLogP3 5.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 394.168 Da
Monoisotopic Mass 394.168 Da
Topological Polar Surface Area 61.700 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 586.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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