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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175650-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$79.90
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Ab175650-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$379.90
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Ab175650-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$949.90
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Ab175650-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,519.90
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Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Conjugated (Mc-VC-PAB-SN38)
| Product Name | Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2 |
|---|---|
| Synonyms | Cell surface glycoprotein Trop 2 antibody | Cell surface glycoprotein Trop-2 antibody | Cell surface glycoprotein Trop2 antibody | Epithelial glycoprotein 1 antibody | GA733 1 antibody | GA7331 antibody | M1S 1 antibody | M1S1 antibody | Membrane componen |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | May function as a growth factor receptor. |
| Host species | Human |
| Specificity | TACSTD2 |
| Conjugation | Mc-VC-PAB-SN38 |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | Antibody of tumor associated calcium signal transducer 2 |
| Product Description |
Sacituzumab govitecan (anti-TROP2) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan (anti-TROP2) shows anticancer activity. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Purity | >90% (SDS-PAGE&SEC) |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1491917-83-9 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Sacituzumab govitecan (anti-TROP2) (Ab175650) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling TROP2 (red) with Sacituzumab govitecan (anti-TROP2) (Ab175650) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Sacituzumab govitecan (anti-TROP2) (Ab175650) - SEC
The purity of Sacituzumab govitecan (anti-TROP2) (Ab175650) is more than 95% verified by HPLC.
Sacituzumab govitecan (anti-TROP2) (Ab175650) - ELISA
Immobilized Recombinant huTROP2 (ECD)-chis protein at 2.0 μg/mL can bind Sacituzumab govitecan (anti-TROP2) (Ab175650) with the EC₅₀ of 5.81 ng/mL.