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Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2, Antibody of tumor associated calcium signal transducer 2

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Mc-VC-PAB-SN38
In stock
Item Number
Ab175650
Grouped product items
SKU Size
Availability
Price Qty
Ab175650-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab175650-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
Ab175650-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$949.90
Ab175650-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,519.90

Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Conjugated (Mc-VC-PAB-SN38)

Basic Description

Product Name Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2
Synonyms Cell surface glycoprotein Trop 2 antibody | Cell surface glycoprotein Trop-2 antibody | Cell surface glycoprotein Trop2 antibody | Epithelial glycoprotein 1 antibody | GA733 1 antibody | GA7331 antibody | M1S 1 antibody | M1S1 antibody | Membrane componen
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms May function as a growth factor receptor.
Host species Human
Specificity TACSTD2
Conjugation Mc-VC-PAB-SN38
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action Antibody of tumor associated calcium signal transducer 2
Product Description

Sacituzumab govitecan (anti-TROP2) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan (anti-TROP2) shows anticancer activity.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Purity >90% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1491917-83-9

Associated Targets(Human)

TACSTD2 Tclin Tumor-associated calcium signal transducer 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Sacituzumab govitecan (anti-TROP2) (Ab175650) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling TROP2 (red) with Sacituzumab govitecan (anti-TROP2) (Ab175650) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Sacituzumab govitecan (anti-TROP2) (Ab175650) - SEC
The purity of Sacituzumab govitecan (anti-TROP2) (Ab175650) is more than 95% verified by HPLC.

Sacituzumab govitecan (anti-TROP2) (Ab175650) - ELISA
Immobilized Recombinant huTROP2 (ECD)-chis protein at 2.0 μg/mL can bind Sacituzumab govitecan (anti-TROP2) (Ab175650) with the EC₅₀ of 5.81 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

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