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S-Methyl-L-cysteine - 98%,substrate for methionine sulfoxide reductase, high purity , CAS No.1187-84-4

1 Citations

COA

Grade & Purity:

≥98%
substrate for methionine sulfoxide reductase

Cas Number: 1187-84-4
Molecular Weight: 135.18
Beilstein Registry Number: 1721675
EC Number: 214-701-6
MDL number: MFCD00002612
PubChem CID: 24417
PubChem SID: 504753199

In stock

Item Number

M116973

Grouped product items
SKU	Size	Availability	Price
M116973-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$17.90
M116973-5g	5g	2	$68.90
M116973-25g	25g	2	$307.90
M116973-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,108.90

System A and <>1 inhibitor

View related series

Glucose Metabolism (1943) Immunology/Inflammation (1929) Metabolic Enzyme/Protease (4860) NF-κB (747) Peptide chemistry (314) Reactive Oxygen Species (309) Side chain protected amino acids (28)

Basic Description

Synonyms	EINECS 243-203-1 \| L-S-Methyl-cysteine \| AKOS000275785 \| CHEBI:45658 \| (2R)-2-azaniumyl-3-(methylsulfanyl)propanoate \| L-Methylcysteine \| GS-3468 \| Q27093260 \| 3-(METHYLTHIO)ALANINE \| L-Cysteine, S-methyl- \| MFCD00002612 \| (R)-2-Amino-3-(methylmercapto)pr
Specifications & Purity	≥98%, substrate for methionine sulfoxide reductase
Biochemical and Physiological Mechanisms	S-Methyl-L-cysteine (SMLC) is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). SMLC is naturally present in garlic, cabbage, and turnips and has been studied as a theurapeutic for neurodegenerative disea
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	substrate for methionine sulfoxide reductase A

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Cysteine and derivatives
        Level8 L-cysteine-S-conjugates

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Cysteine and derivatives
Direct Parent	L-cysteine-S-conjugates
Alternative Parents	L-alpha-amino acids Amino acids Sulfenyl compounds Monocarboxylic acids and derivatives Dialkylthioethers Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic acyclic compounds
Substituents	L-cysteine-s-conjugate - Alpha-amino acid - L-alpha-amino acid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Thioether - Sulfenyl compound - Dialkylthioether - Carbonyl group - Amine - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Primary aliphatic amine - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxide - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as l-cysteine-s-conjugates. These are compounds containing L-cysteine where the thio-group is conjugated.
External Descriptors	S-alkyl-L-cysteine
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HeLa (62764 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KIF11 Tchem Kinesin-like protein 1 (1720 Activities)

Discover Target: KIF11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 Activities)

Discover Target: Slc1a5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504753199
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753199
IUPAC Name	(2R)-2-amino-3-methylsulfanylpropanoic acid
INCHI	InChI=1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
InChIKey	IDIDJDIHTAOVLG-VKHMYHEASA-N
Smiles	CSCC(C(=O)O)N
Isomeric SMILES	CSC[C@@H](C(=O)O)N
WGK Germany	3
Molecular Weight	135.18
Beilstein	1721675
Reaxy-Rn	2038947
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2038947&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
J2409008	Certificate of Analysis	Oct 14, 2024	M116973
K2112202	Certificate of Analysis	Aug 04, 2023	M116973
K2112201	Certificate of Analysis	Aug 04, 2023	M116973
K2112210	Certificate of Analysis	Aug 04, 2023	M116973
K2112211	Certificate of Analysis	Aug 04, 2023	M116973
B1928107	Certificate of Analysis	Sep 22, 2022	M116973

Chemical and Physical Properties

Specific Rotation[α]	-30 ° (C=2, H2O)
Melt Point(°C)	240°C
Molecular Weight	135.190 g/mol
XLogP3	-2.700
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	135.035 Da
Monoisotopic Mass	135.035 Da
Topological Polar Surface Area	88.600 Å²
Heavy Atom Count	8
Formal Charge	0
Complexity	86.100
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jing Nie, Rui Weng, Chunlin Li, Xiuhua Liu, Fang Wang, Karyne M. Rogers, Yongzhong Qian, Yongzhi Zhang, Yuwei Yuan. (2022) Chemometric origin classification of Chinese garlic using sulfur-containing compounds, assisted by stable isotopes and bioelements. FOOD CHEMISTRY, 394 (133557).

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