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RU-301 - 10mM in DMSO, high purity , CAS No.1110873-99-8

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1110873-99-8
Molecular Weight: 480.46
PubChem CID: 40135492

In stock

Item Number

R420616

Grouped product items
SKU	Size	Availability	Price	Qty
R420616-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Axl Inhibitors

View related series

Compound libraries (12325) Receptor Tyrosine Kinase (1260)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information RU-301 RU-301 is a pan- TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively. Targets Axl (Cell-free assay); Axl (Cell-free assay) 10 μM; 12 μM(Kd)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives
      - Level5 Sulfanylbenzoic acids and derivatives
        Level6 O-sulfanylbenzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Sulfanylbenzoic acids and derivatives
Direct Parent	O-sulfanylbenzoic acids and derivatives
Alternative Parents	Trifluoromethylbenzenes Benzamides Nitrobenzenes Aniline and substituted anilines Benzoyl derivatives Nitroaromatic compounds Thiophenol ethers Phenylalkylamines Secondary alkylarylamines Alkylarylthioethers Vinylogous thioesters Heteroaromatic compounds Isoxazoles Secondary carboxylic acid amides Amino acids and derivatives Sulfenyl compounds Oxacyclic compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organic oxoazanium compounds Organic zwitterions Organofluorides Organic salts Hydrocarbon derivatives Organooxygen compounds Organic oxides Alkyl fluorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	O-sulfanylbenzoic acid or derivatives - Trifluoromethylbenzene - Benzamide - Nitrobenzene - Benzoyl - Aryl thioether - Nitroaromatic compound - Thiophenol ether - Aniline or substituted anilines - Phenylalkylamine - Alkylarylthioether - Secondary aliphatic/aromatic amine - Vinylogous thioester - Azole - Heteroaromatic compound - Isoxazole - Organic nitro compound - Carboxamide group - C-nitro compound - Secondary carboxylic acid amide - Amino acid or derivatives - Oxacycle - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Organic 1,3-dipolar compound - Organic oxoazanium - Propargyl-type 1,3-dipolar organic compound - Secondary amine - Allyl-type 1,3-dipolar organic compound - Thioether - Sulfenyl compound - Organohalogen compound - Amine - Organic oxygen compound - Alkyl halide - Organic oxide - Organofluoride - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Alkyl fluoride - Hydrocarbon derivative - Organic zwitterion - Organic salt - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as o-sulfanylbenzoic acids and derivatives. These are benzoic acids (or derivatives) which bear a sulfanyl group (R-SH) attached to the benzene ring at positions 1 and 2, respectively.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	4.272
HBD Count	2
Rotatable Bond	10

Names and Identifiers

IUPAC Name	2-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-N-[2-[2-nitro-4-(trifluoromethyl)anilino]ethyl]benzamide
INCHI	InChI=1S/C21H19F3N4O4S/c1-13-10-15(32-27-13)12-33-19-5-3-2-4-16(19)20(29)26-9-8-25-17-7-6-14(21(22,23)24)11-18(17)28(30)31/h2-7,10-11,25H,8-9,12H2,1H3,(H,26,29)
InChIKey	BPHPWPNHNGXNPR-UHFFFAOYSA-N
Smiles	CC1=NOC(=C1)CSC2=CC=CC=C2C(=O)NCCNC3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
Isomeric SMILES	CC1=NOC(=C1)CSC2=CC=CC=C2C(=O)NCCNC3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
PubChem CID	40135492
Molecular Weight	480.46

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

DMSO(mg / mL) Max Solubility	96
DMSO(mM) Max Solubility	199.80851683803
Water(mg / mL) Max Solubility	＜1
Molecular Weight	480.500 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	480.108 Da
Monoisotopic Mass	480.108 Da
Topological Polar Surface Area	138.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	666.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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