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RSL3 - 98%, high purity , CAS No.1219810-16-8

9 Citations COA COA
En stock
Item Number
R302648
Articles du produit groupé
SKU Taille
Disponibilité
 Prix Qté
R302648-1mg
1mg
2
9,90$US
R302648-5mg
5mg
2
29,90$US
R302648-10mg
10mg
1
39,90$US
R302648-25mg
25mg
2
79,90$US
R302648-50mg
50mg
2
119,90$US
R302648-100mg
100mg
2
189,90$US
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Induces ferroptosis; inhibits glutathione peroxidase 4 (GPX4)

View related series
Apoptosis (4276) Atg and Atg-related Protein (135) Autophagy (1917) Ferroptosis (356) Glucose Metabolism (1943) Glutathione Peroxidase (23) Metabolic Enzyme/Protease (4860)

Description générale

Synonymes (1S,3R)-RSL3 | 1S,3R-RSL3 | (1S,3R)-Methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Spécifications et pureté Moligand™, ≥98%
Mécanismes biochimiques et physiologiques Glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levelsin vitro. Inhibits tumor formation and progressionin vivo.
Température de stockage Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Grade Moligand™
Product Description

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Alkaloids and derivatives
Classe Harmala alkaloids
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Harmala alkaloids
Alternative Parents Alpha amino acid esters  Beta carbolines  3-alkylindoles  Benzoic acid esters  Benzoyl derivatives  Dicarboxylic acids and derivatives  Methyl esters  Heteroaromatic compounds  Tertiary carboxylic acid amides  Chloroacetamides  Pyrroles  Azacyclic compounds  Hydrocarbon derivatives  Carbonyl compounds  Organochlorides  Organonitrogen compounds  Organopnictogen compounds  Alkyl chlorides  Organic oxides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Harman - Alpha-amino acid ester - Beta-carboline - Pyridoindole - Alpha-amino acid or derivatives - Benzoate ester - 3-alkylindole - Benzoic acid or derivatives - Indole - Indole or derivatives - Benzoyl - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Benzenoid - Methyl ester - Tertiary carboxylic acid amide - Pyrrole - Chloroacetamide - Heteroaromatic compound - Carboxamide group - Carboxylic acid ester - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Organic nitrogen compound - Organohalogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organochloride - Organopnictogen compound - Alkyl chloride - Organic oxygen compound - Organooxygen compound - Alkyl halide - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as harmala alkaloids. These are compounds with a structure based on harmaline, harmine, harmalol, harman or a derivative of those parents. These parents are beta-carbolines, consisting of a pyrimidine fused to the pyrrole moiety of an indole to form a pyrido[3,4-b]indole.
External Descriptors Not available

Cibles associées (humaines)

GPX4 Tchem Phospholipid hydroperoxide glutathione peroxidase (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
Calu-1 (518 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-1080 (3966 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Cibles associées (non humaines)

HT-22 (3261 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
4T1 (1737 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mécanismes d'action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name Références

Noms et identifiants

Pubchem Sid 504760629
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504760629
IUPAC Name methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
INCHI InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1
InChIKey TXJZRSRTYPUYRW-NQIIRXRSSA-N
Smiles COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
Isomères SMILES COC(=O)[C@H]1CC2=C([C@@H](N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
PubChem CID 1750826
Poids moléculaire 440.88

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

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Analytical Chart:

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55 results found

Lot Number Certificate Type Date Article
E2512463 Certificate of Analysis Apr 07, 2025 R302648
E2512464 Certificate of Analysis Apr 07, 2025 R302648
E2512465 Certificate of Analysis Apr 07, 2025 R302648
E2512466 Certificate of Analysis Apr 07, 2025 R302648
E2512467 Certificate of Analysis Apr 07, 2025 R302648
E2512468 Certificate of Analysis Apr 07, 2025 R302648
K2413432 Certificate of Analysis Nov 04, 2024 R302648
K2413417 Certificate of Analysis Nov 04, 2024 R302648
K2413437 Certificate of Analysis Nov 04, 2024 R302648
K2413441 Certificate of Analysis Nov 04, 2024 R302648
F2403193 Certificate of Analysis May 08, 2024 R302648
F2403194 Certificate of Analysis May 08, 2024 R302648
F2403195 Certificate of Analysis May 08, 2024 R302648
F2403196 Certificate of Analysis May 08, 2024 R302648
F2403197 Certificate of Analysis May 08, 2024 R302648
K2307204 Certificate of Analysis Oct 30, 2023 R302648
K2307208 Certificate of Analysis Oct 30, 2023 R302648
K2307211 Certificate of Analysis Oct 30, 2023 R302648
K2307228 Certificate of Analysis Oct 30, 2023 R302648
K2307209 Certificate of Analysis Oct 30, 2023 R302648
K2307217 Certificate of Analysis Oct 30, 2023 R302648
K2307218 Certificate of Analysis Oct 30, 2023 R302648
K2307206 Certificate of Analysis Oct 30, 2023 R302648
K2307210 Certificate of Analysis Oct 30, 2023 R302648
K2307205 Certificate of Analysis Oct 30, 2023 R302648
K2307248 Certificate of Analysis Oct 30, 2023 R302648
K2307215 Certificate of Analysis Oct 30, 2023 R302648
H2323567 Certificate of Analysis Aug 02, 2023 R302648
H2323568 Certificate of Analysis Aug 02, 2023 R302648
H2323538 Certificate of Analysis Aug 02, 2023 R302648
H2323551 Certificate of Analysis Aug 02, 2023 R302648
H2323566 Certificate of Analysis Aug 02, 2023 R302648
H2323512 Certificate of Analysis Aug 02, 2023 R302648
C2317090 Certificate of Analysis Mar 09, 2023 R302648
C2317088 Certificate of Analysis Mar 09, 2023 R302648
C2317023 Certificate of Analysis Mar 09, 2023 R302648
C23161107 Certificate of Analysis Mar 09, 2023 R302648
B2320619 Certificate of Analysis Dec 30, 2022 R302648
B2320614 Certificate of Analysis Dec 30, 2022 R302648
B2320618 Certificate of Analysis Dec 30, 2022 R302648
B2320518 Certificate of Analysis Dec 30, 2022 R302648
B2320621 Certificate of Analysis Dec 30, 2022 R302648
B2320620 Certificate of Analysis Dec 30, 2022 R302648
K2212561 Certificate of Analysis Sep 02, 2022 R302648
K2212619 Certificate of Analysis Sep 02, 2022 R302648
K2212562 Certificate of Analysis Sep 02, 2022 R302648
K2212608 Certificate of Analysis Sep 02, 2022 R302648
K2212592 Certificate of Analysis Sep 02, 2022 R302648
K2212620 Certificate of Analysis Sep 02, 2022 R302648
G2220797 Certificate of Analysis Jun 17, 2022 R302648
G2220796 Certificate of Analysis Jun 17, 2022 R302648
G2220795 Certificate of Analysis Jun 17, 2022 R302648
G2220794 Certificate of Analysis Jun 17, 2022 R302648
G2220793 Certificate of Analysis Jun 17, 2022 R302648
G2220792 Certificate of Analysis Jun 17, 2022 R302648

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Propriétés chimiques et physiques

Solubilité Solvent:DMSO, Max Conc. mg/mL: 44.09, Max Conc. mM: 100
Sensibilité Moisture sensitive
Poids moléculaire 440.900 g/mol
XLogP3 3.500
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 6
Exact Mass 440.114 Da
Monoisotopic Mass 440.114 Da
Topological Polar Surface Area 88.700 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 695.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li.  (2024)  A potent GPX4 degrader to induce ferroptosis in HT1080 cells.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,  265  (116110).  [PMID:38194774] [10.1016/j.ejmech.2023.116110]
2. Weili Wu, Yingying Zhao, Baifu Qin, Xin Jiang, Chuyue Wang, Rong Hu, Rui Ma, Mong-Hong Lee, Huanliang Liu, Kai Li, Ping Yuan.  (2023)  Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.  EBioMedicine,  93    [PMID:37343364] [10.1016/j.ebiom.2023.104650]
3. Zhao Hongting, Zhang Meng, Zhang Jinghua, Sun Zichen, Zhang Wenxin, Dong Weichen, Cheng Chen, Yao Yongzhong, Li Kuanyu.  (2023)  Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.  Cell and Bioscience,  13  (1): (1-15).  [PMID:37179385] [10.1186/s13578-023-01044-0]
4. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan.  (2023)  Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis.  Phytochemistry Letters,  55  (80).  [PMID:] [10.1016/j.phytol.2023.04.003]
5. Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang.  (2022)  Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice.  Frontiers in Cell and Developmental Biology,  10  (1014243).  [PMID:36438553] [10.3389/fcell.2022.1014243]
6. Yi-Xuan Zeng, Ni-Ren Li, Bing-Ying Deng, Yu-Feng Gu, Si-Fan Lu, Yi Liu.  (2025)  Coix Seed Oil Alleviates DSS-Induced Ulcerative Colitis via Intestinal Barrier Repair and Ferroptosis Regulation.  Journal of Inflammation Research,      [PMID:39995826] [10.2147/JIR.S501745]
7. Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang.  (2025)  Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.  Marine Drugs,  23  (1): (49).  [PMID:39852551] [10.3390/md23010049]
8. Wuyang Shi, Shibo Sun, Haowen Liu, Yao Meng, Kangshuai Ren, Guoying Wang, Minghui Liu, Jiaqi Wu, Yue Zhang, Huang Huang, Meiyun Shi, Weiping Xu, Qiang Ma, Bingbing Sun, Jianqiang Xu.  (2024)  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.  Redox Biology,  70  (103050).  [PMID:38277963] [10.1016/j.redox.2024.103050]
9. Deshan Yao, Liuxiang Bao, Sichuan Wang, Meng Tan, Yuanyuan Xu, Tianxu Wu, Zhengang Zhang, Kaizheng Gong.  (2024)  Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7A11/GPX4 axis in mice.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:38734270] [10.1016/j.freeradbiomed.2024.05.012]

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