Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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R109804-10mg
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10mg |
3
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$19.90
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R109804-20mg
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20mg |
3
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$31.90
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R109804-100mg
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100mg |
3
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$99.90
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R109804-500mg
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500mg |
3
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$299.90
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R109804-1g
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1g |
2
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$499.90
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R109804-5g
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5g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$1,699.90
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Polyphenol with anti-oxidative and anti-inflammatory properties.
| Synonyms | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid | HMS3649C22 | SMR000445579 | MFCD00017740 | AS-35341 | R-(+)-2-(3,4-Dih |
|---|---|
| Specifications & Purity | analytical standard, ≥97% |
| Biochemical and Physiological Mechanisms | Rosmarinic acid has antioxidant, anti-inflammatory, and antibacterial activities. It has broad application prospects in cognitive ability, Alzheimer's disease prevention, kidney disease treatment, cardiac protection, and tumor chemoprevention. |
| Storage Temp | Store at 2-8°C |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | analytical standard |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
An activator of GPR35. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Phenylpropanoids and polyketides |
| Class | Cinnamic acids and derivatives |
| Subclass | Hydroxycinnamic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Coumaric acids and derivatives |
| Alternative Parents | Cinnamic acid esters Phenylpropanoic acids Styrenes Catechols Fatty acid esters 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Dicarboxylic acids and derivatives Enoate esters Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Coumaric acid or derivatives - Cinnamic acid ester - 3-phenylpropanoic-acid - Catechol - Styrene - 1-hydroxy-4-unsubstituted benzenoid - Fatty acid ester - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Fatty acyl - Dicarboxylic acid or derivatives - Benzenoid - Monocyclic benzene moiety - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carboxylic acid ester - Carboxylic acid - Carboxylic acid derivative - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as coumaric acids and derivatives. These are aromatic compounds containing Aromatic compounds containing a cinnamic acid moiety (or a derivative thereof) hydroxylated at the C2 (ortho-), C3 (meta-), or C4 (para-) carbon atom of the benzene ring. |
| External Descriptors | rosmarinic acid |
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| IUPAC Name | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid |
|---|---|
| INCHI | InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 |
| InChIKey | DOUMFZQKYFQNTF-WUTVXBCWSA-N |
| Smiles | OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2 |
| Isomeric SMILES | C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O |
| WGK Germany | 3 |
| PubChem CID | 5281792 |
| Molecular Weight | 360.31 |
| Beilstein | 2227587 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 04, 2025 | R109804 | |
| Certificate of Analysis | Mar 04, 2025 | R109804 | |
| Certificate of Analysis | May 09, 2024 | R109804 | |
| Certificate of Analysis | May 09, 2024 | R109804 | |
| Certificate of Analysis | May 09, 2024 | R109804 | |
| Certificate of Analysis | May 09, 2024 | R109804 | |
| Certificate of Analysis | Feb 01, 2024 | R109804 | |
| Certificate of Analysis | Oct 08, 2023 | R109804 | |
| Certificate of Analysis | Sep 21, 2023 | R109804 | |
| Certificate of Analysis | Sep 21, 2023 | R109804 | |
| Certificate of Analysis | Sep 06, 2023 | R109804 | |
| Certificate of Analysis | Jun 01, 2023 | R109804 | |
| Certificate of Analysis | Jun 01, 2023 | R109804 | |
| Certificate of Analysis | Jan 13, 2023 | R109804 | |
| Certificate of Analysis | Nov 10, 2022 | R109804 | |
| Certificate of Analysis | Apr 27, 2022 | R109804 |
| Solubility | Soluble in water (100 mM), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~15 mg/ml). |
|---|---|
| Sensitivity | air sensitive |
| Melt Point(°C) | 171-175°C |
| Molecular Weight | 360.300 g/mol |
| XLogP3 | 2.400 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 360.085 Da |
| Monoisotopic Mass | 360.085 Da |
| Topological Polar Surface Area | 145.000 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 519.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
Starting at $19.90
| 1. Edidiong Joseph Bassey, Jun-Hu Cheng, Da-Wen Sun. (2024) Comparative elucidation of bioactive and antioxidant properties of red dragon fruit peel as affected by electromagnetic and conventional drying approaches. FOOD CHEMISTRY, 439 (138118). |
| 2. Liu Chengyi, Du Guicai, Guo Qunqun, Li Ronggui, He Hongwei, Li Changming. (2023) Synergistic antibacterial performance of rosemarinic acid - graphene oxide in electrospun polylactic acid membranes for air filtration. JOURNAL OF POLYMER RESEARCH, 30 (12): (1-10). |
| 3. Jingyuan Zeng, Xican Li, Rongxin Cai, Chunhou Li, Shaoman Chen. (2023) Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation. JOURNAL OF FOOD AND DRUG ANALYSIS, 31 (3): ( 534–551). |
| 4. Xiaxi Pan, Guixin Chen, Ting Xu, Lingyue Kong, Xinying Li, Defu Li, Changdao Mu, Zhilang Xu, Liming Ge. (2023) Gelatin-Based Active Edible Film with pH-Sensing for Maintaining and Monitoring Fish Freshness. ACS Food Science & Technology, 3 (8): (1366–1375). |
| 5. Linghong Zhang, Zhongwu Bei, Tao Li, Zhiyong Qian. (2023) An injectable conductive hydrogel with dual responsive release of rosmarinic acid improves cardiac function and promotes repair after myocardial infarction. Bioactive Materials, 29 (132). |
| 6. Nan Hu, Lin Chen, Yunpeng Li, Nan Yao, Huizhen Li, Zhijun Zhang. (2023) Foam fractionation of rosmarinic acid from perilla leaves using surface-modified Al2O3 nanoparticle as frother and collector. INDUSTRIAL CROPS AND PRODUCTS, 197 (116633). |
| 7. Zhixin Xiao, Min Liu, Wentao Bi, David Da Yong Chen. (2023) Ionic liquid as hydrogen bond acceptor in the extraction of nutritional natural products. FOOD CHEMISTRY, 412 (135589). |
| 8. Ming Meng, Haofang Wan, Yida Bao, Yu He, Chang Li, Haitong Wan. (2023) Rapid identification, quantitation, and antioxidant activity evaluation of the components in Guanxin Shutong capsule with liquid chromatography and mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 224 (115194). |
| 9. Xie Lixia, Li Zhineng, Li Haitao, Sun Jiayu, Liu Xueying, Tang Jianxin, Lin Xizhu, Xu Laijun, Zhu Yuefang, Liu Zhi, Wang Tong. (2023) Fast Quantitative Determination of Principal Phenolic Anti-oxidants in Rosemary Using Ultrasound-Assisted Extraction and Chemometrics-Enhanced HPLC–DAD Method. Food Analytical Methods, 16 (2): (386-400). |
| 10. Jingtong Xia, Minhua Qian, Jiahao Zhou, Zhaoyan Wang, Hongli Li, Lei Zhou, Qiaosheng Pu. (2022) Integrated strategy of derivatization and separation for sensitive analysis of salvianolic acids using capillary electrophoresis with laser-induced fluorescence detection. JOURNAL OF CHROMATOGRAPHY A, 1685 (463607). |
| 11. Given Chisha, Chunlu Li, Lei Xiao, Bo Wang, Yueyuan Chen, Zhifang Cui. (2022) Multiscale mechanism exploration and experimental optimization for rosmarinic acid extraction from Rosmarinus officinalis using natural deep eutectic solvents. INDUSTRIAL CROPS AND PRODUCTS, 188 (115637). |
| 12. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). |
| 13. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 |
| 14. Meixuan Liu, Sha Liu, Xiaosu Zhu, Yiying Sun, Linyu Su, Hairong Yu, Deshuai Liu, Ying Li, Yuan Du, Rongxia Liu, Kaoxiang Sun. (2022) Tanshinone IIA-Loaded Micelles Functionalized with Rosmarinic Acid: A Novel Synergistic Anti-Inflammatory Strategy for Treatment of Atherosclerosis. JOURNAL OF PHARMACEUTICAL SCIENCES, 111 (2827). |
| 15. Changan Zhu, Shaofang Wu, Ting Sun, Zhiwen Zhou, Zhangjian Hu, Jingquan Yu. (2021) Rosmarinic Acid Delays Tomato Fruit Ripening by Regulating Ripening-Associated Traits. Antioxidants, 10 (11): (1821). |
| 16. Yanjun An, Jiandong Zhao, Yourui Zhang, Wen Wu, Jiangtao Hu, Haosen Hao, Yu Qiao, Ying Tao, Liping An. (2021) Rosmarinic Acid Induces Proliferation Suppression of Hepatoma Cells Associated with NF-κB Signaling Pathway. Asian Pacific Journal of Cancer Prevention, 22 (5): ( 1623–1631). |
| 17. Yunsheng Liu, Xiangping Xu, Han Tang, Yuchen Pan, Bing Hu, Guodong Huang. (2021) Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 47 (5): (1-11). |
| 18. Wenwei Zhong, Yingnan Zhao, Shunquan Chen, Jialun Zhong, LiWei Guo, Dongyang Zheng, Chun Xie, Chao Ji, Yi Guo, Guangxi Dong, Fengyuan Zhang, Alicia An, Shaoping Li, Sheng Li. (2021) Resources recycle of traditional Chinese medicine (TCM) wastewater 1: Effectiveness of the UF-MD hybrid system and MD process optimization. DESALINATION, 504 (114953). |
| 19. Hongjie Dai, Xueke Chen, Lin Peng, Liang Ma, Yi Sun, Lin Li, Qiang Wang, Yuhao Zhang. (2020) The mechanism of improved myosin gel properties by low dose rosmarinic acid addition during gel formation. FOOD HYDROCOLLOIDS, 106 (105869). |
| 20. Xu Wen-hao, Wang Han-tao, Sun Ying, Xue Zhen-cheng, Liang Ming-li, Su Wei-ke. (2020) Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (4): (551-560). |
| 21. Houmei Liu, Hui Yu, Pian Jin, Mi Jiang, Guozheng Zhu, Yu Duan, Ziyuan Yang, Hongdeng Qiu. (2020) Preparation of mesoporous silica materials functionalized with various amino-ligands and investigation of adsorption performances on aromatic acids. CHEMICAL ENGINEERING JOURNAL, 379 (122405). |
| 22. Yusong Jin, Yunhui Zhang, Dongmei Liu, Dewen Liu, Chunying Zhang, Huijuan Qi, Huiyan Gu, Lei Yang, Zhiqiang Zhou. (2019) Efficient Homogenization-Ultrasound-Assisted Extraction of Anthocyanins and Flavonols from Bog Bilberry (Vaccinium uliginosum L.) Marc with Carnosic Acid as an Antioxidant Additive. MOLECULES, 24 (14): (2537). |
| 23. Hongxia Liu, Huifang Zhao, Lianfei Lyu, Zhengjin Huang, Sufan Fan, Wenlong Wu, Weilin Li. (2019) Synergistic effect of natural antifungal agents for postharvest diseases of blackberry fruits. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 99 (7): (3343-3349). |
| 24. Zili Guo, Xianrui Liang, Yuanyuan Xie. (2019) Qualitative and quantitative analysis on the chemical constituents in Orthosiphon stamineus Benth. using ultra high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 164 (135). |
| 25. Liming Ge, Mingjin Zhu, Xinying Li, Yongbin Xu, Xiaonan Ma, Rong Shi, Defu Li, Changdao Mu. (2018) Development of active rosmarinic acid-gelatin biodegradable films with antioxidant and long-term antibacterial activities. FOOD HYDROCOLLOIDS, 83 (308). |
| 26. Jia Zou, Yang Chen, Maggie Pui Man Hoi, Jun Li, Tao Wang, Ying Zhang, Yu Feng, Jianli Gao, Simon Ming Yuen Lee, Guozhen Cui. (2018) Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza). Evidence-based Complementary and Alternative Medicine, 2018 (9387568). |
| 27. Liu Jingjing, Li Xican, Lin Jian, Li Yunrong, Wang Tingting, Jiang Qian, Chen Dongfeng. (2016) Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative stress: a bioevaluation and mechanistic chemistry. BMC Complementary and Alternative Medicine, 16 (1): (1-10). |
| 28. Shan Ye, Wang Dan-Dan, Xu Yu-Xia, Wang Chu, Cao Lan, Liu Yun-Sheng, Zhu Cui-Qing. (2015) Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid. JOURNAL OF ALZHEIMERS DISEASE, 49 (3): (829-844). |
| 29. Kitty S.C. Tang, Izabela Konczak, Jian Zhao. (2016) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). FOOD CHEMISTRY, 192 (698). |
| 30. Xin Peng, Xiangchao Wang, Wei Qi, Rongxin Su, Zhimin He. (2016) Affinity of rosmarinic acid to human serum albumin and its effect on protein conformation stability. FOOD CHEMISTRY, 192 (178). |
| 31. Xin Peng, Xiangchao Wang, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He. (2015) Deciphering the binding patterns and conformation changes upon the bovine serum albumin–rosmarinic acid complex. Food & Function, 6 (8): (2712-2726). |
| 32. Xin Peng, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He. (2015) Elucidating the Influence of Gold Nanoparticles on the Binding of Salvianolic Acid B and Rosmarinic Acid to Bovine Serum Albumin. PLoS One, 10 (4): (e0118274). |
| 33. Xican Li. (2013-07-23) Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radical-scavenging.. Food chemistry, 141 ((3)): (2083-2088). |
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