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Rolipram (ZK-62711) - 10mM in DMSO, high purity , CAS No.61413-54-5(DMSO), Inhibitor of phosphodiesterase 4A;Inhibitor of phosphodiesterase 4B;Inhibitor of phosphodiesterase 4C;Inhibitor of phosphodiesterase 4D

COA COA
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Item Number
R408046
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R408046-1ml
1ml
Available within 4-8 weeks(?)
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$173.90
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PDE4 Selective Inhibitors

View related series
Compound libraries (12325)

Basic Description

Synonyms SB 95952 | 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of phosphodiesterase 4A;Inhibitor of phosphodiesterase 4B;Inhibitor of phosphodiesterase 4C;Inhibitor of phosphodiesterase 4D
Product Description

Information

ThePDE4selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurifiedPDE4BandPDE4Dactivities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
In vitro


In vivo


Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Associated Targets(Human)

TNF Tclin Tumor necrosis factor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDE4C Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDE4B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Smiles COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3
Molecular Weight 275.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 74 mg/mL (199.79 mM); Ethanol: 3 mg/mL (8.09 mM); Water: Insoluble;

Solution Calculators

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