Ro3280 - 10mM in DMSO, high purity , CAS No.1062243-51-9, Inhibitor of FER tyrosine kinase;Inhibitor of polo like kinase 1;Inhibitor of TTK protein kinase
Ro3280 - 10mM in DMSO, high purity , CAS No.1062243-51-9, Inhibitor of FER tyrosine kinase;Inhibitor of polo like kinase 1;Inhibitor of TTK protein kinase
Potent and selective PLK inhibitor (IC50= 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells linesin vitroand induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of FER tyrosine kinase;Inhibitor of polo like kinase 1;Inhibitor of TTK protein kinase
This compound belongs to the class of organic compounds known as pyrimidodiazepines. These are compounds containing a pyrimidoazepine moiety, which consists of a pyrimidine fused to a piperazine ring by a bond. Pyrimidine is 6-membered ring consisting of five carbon atoms and two nitrogen atoms at ring positions 1 and 3. Diazepine is a 7-membered ring consisting of five carbon atoms and two nitrogen centers.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
