RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.
Storage Temp
Store at -80°C
Shipped In
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Product Description
RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes
In Vitro
RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice. RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and C max (1140 μg/mL) following oral administration (10 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 10 weeks old male C57BL/6J miceDosage: 50 mg/kg Administration: Oral administration Result: Reduced blood glucose levels. Animal Model: C57BL/6J mice Dosage: 10 mg/kg (Pharmacokinetic Analysis Administration: Oral administration Result: Oral bioavailability (92.8%), C max (1140 μg/mL), T max (3.3 h).
