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RO-28-1675 - 99%, high purity , CAS No.300353-13-3

COA

Grade & Purity:

≥99%

Cas Number: 300353-13-3
Molecular Weight: 378.51

In stock

Item Number

R651013

Grouped product items
SKU	Size	Availability	Price	Qty
R651013-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$258.90
R651013-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$444.90

View related series

Glucokinase (19) Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes In Vitro RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice. RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and C max (1140 μg/mL) following oral administration (10 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 10 weeks old male C57BL/6J miceDosage: 50 mg/kg Administration: Oral administration Result: Reduced blood glucose levels. Animal Model: C57BL/6J mice Dosage: 10 mg/kg (Pharmacokinetic Analysis Administration: Oral administration Result: Oral bioavailability (92.8%), C max (1140 μg/mL), T max (3.3 h). Form:Solid IC50& Target:EC50: 54 nM (glucokinase)

Names and Identifiers

Smiles	O=C([C@@H](C1=CC=C(C=C1)S(=O)(C)=O)CC2CCCC2)NC3=NC=CS3
Molecular Weight	378.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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