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RN-1734 - 98%, high purity , CAS No.946387-07-1, Channel blocker of TRPV4

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RN-1734 - 98%, high purity , CAS No.946387-07-1, Channel blocker of TRPV4

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 946387-07-1
Molecular Weight: 353.31
PubChem CID: 3601086
PubChem SID: 504762628

In stock

Item Number

R276507

Grouped product items
SKU	Size	Availability	Price
R276507-5mg	5mg	2	$64.90
R276507-10mg	10mg	3	$90.90
R276507-25mg	25mg	2	$204.90
R276507-50mg	50mg	2	$416.90
R276507-100mg	100mg	2	$730.90
R276507-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,644.90

Novel, selective TRPV4 antagonist

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181) TRPV4 Channel blocker (8)

Basic Description

Synonyms	HY-19975 \| AKOS005110777 \| BDBM50426575 \| SCHEMBL20304906 \| RN-1734, >=98% (HPLC) \| TRPV4 Antagonist I, RN-1734 \| BCP28123 \| TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 \| 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide \| HMS3414D05
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	RN-1734 is a selective TRPV4 antagonist.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPV4
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at Room Temperature. Application RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Benzenesulfonyl compounds Dichlorobenzenes Organosulfonamides Aryl chlorides Aminosulfonyl compounds Dialkylamines Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Benzenesulfonamide - Benzenesulfonyl group - 1,3-dichlorobenzene - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Organosulfonic acid amide - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Secondary aliphatic amine - Secondary amine - Organohalogen compound - Organosulfur compound - Amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (7 Activities)

Discover Target: TRPV4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504762628
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504762628
IUPAC Name	2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
INCHI	InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
InChIKey	IHYZMEAZAIFMTN-UHFFFAOYSA-N
Smiles	CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
Isomeric SMILES	CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
PubChem CID	3601086
Molecular Weight	353.31

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
A2208456	Certificate of Analysis	Oct 21, 2022	R276507
A2208284	Certificate of Analysis	Oct 21, 2022	R276507
A2208370	Certificate of Analysis	Oct 21, 2022	R276507
A2208359	Certificate of Analysis	Oct 21, 2022	R276507
A2208362	Certificate of Analysis	Oct 21, 2022	R276507
A2208286	Certificate of Analysis	Oct 21, 2022	R276507

Chemical and Physical Properties

Solubility	Chloroform (Slightly), Methanol (Slightly)
Molecular Weight	353.300 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	352.078 Da
Monoisotopic Mass	352.078 Da
Topological Polar Surface Area	57.800 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	410.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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