RKI-1447 - 10mM in DMSO, high purity , CAS No.1342278-01-6, Inhibitor of CDC42 binding protein kinase alpha;Inhibitor of DM1 protein kinase;Inhibitor of LIM domain kinase 1;Inhibitor of myosin light chain kinase;Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of protein kinase N1;Inhibitor of Rho associated c
RKI-1447 - 10mM in DMSO, high purity , CAS No.1342278-01-6, Inhibitor of CDC42 binding protein kinase alpha;Inhibitor of DM1 protein kinase;Inhibitor of LIM domain kinase 1;Inhibitor of myosin light chain kinase;Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of protein kinase N1;Inhibitor of Rho associated c
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Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of CDC42 binding protein kinase alpha;Inhibitor of DM1 protein kinase;Inhibitor of LIM domain kinase 1;Inhibitor of myosin light chain kinase;Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of protein kinase N1;Inhibitor of Rho associated c
Product Description
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.
This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
