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RK-682 - 95%, high purity , CAS No.154639-24-4

    Grade & Purity:
  • ≥95%
In stock
Item Number
R275023
Grouped product items
SKU Size
Availability
Price Qty
R275023-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$532.90
R275023-200μg
200μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$138.90

Potent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor

View related series
Glucose Metabolism (1943)

Basic Description

Synonyms (R)-3-Hexadecanoyl-5-hydroxymethyltetronic acid | (R)-4-Hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone | (2R)-4-Hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
Specifications & Purity ≥95%
Biochemical and Physiological Mechanisms Potent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor (IC 50 values are 5.5, 54 and 2-11.6 μM at PTP1B, CD45 and VHR respectively). Inhibits cell cycle progression at G1/S transition.
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Dihydrofurans
Subclass Furanones
Intermediate Tree Nodes Not available
Direct Parent Butenolides
Alternative Parents Vinylogous acids  Enoate esters  Lactones  Ketones  Oxacyclic compounds  Monocarboxylic acids and derivatives  Enols  Primary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents 2-furanone - Vinylogous acid - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carboxylic acid ester - Ketone - Lactone - Carboxylic acid derivative - Enol - Oxacycle - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxide - Alcohol - Organic oxygen compound - Carbonyl group - Organooxygen compound - Primary alcohol - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.
External Descriptors Not available

Associated Targets(Human)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALB Tchem Serum albumin (2651 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lyz1 Lysozyme C (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
INCHI InChI=1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3
InChIKey KZTSLHQKWLYYAC-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O
PubChem CID 54685915
Molecular Weight 368.5

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
G2219907 Certificate of Analysis May 15, 2024 R275023
G2219908 Certificate of Analysis May 15, 2024 R275023

Chemical and Physical Properties

Solubility Soluble in DMSO to 50 mM and in ethanol to 25 mM
Molecular Weight 368.500 g/mol
XLogP3 6.700
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 16
Exact Mass 368.256 Da
Monoisotopic Mass 368.256 Da
Topological Polar Surface Area 83.800 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 455.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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