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Rivastigmine Tartrate - ≥98%, high purity , Cholinesterases; ACHE & BCHE inhibitor, CAS No.129101-54-8, Cholinesterases; ACHE & BCHE inhibitor

    Grade & Purity:
  • ≥98%
In stock
Item Number
R129987
Grouped product items
SKU Size
Availability
Price Qty
R129987-250mg
250mg
3
$46.90
R129987-1g
1g
3
$142.90
R129987-5g
5g
2
$495.90

Acetylcholinesterase and butyrylcholinesterase inhibitor

Basic Description

Synonyms Q27133236 | AKOS022179413 | AS-14385 | AKOS003617905 | Carbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) | HMS3884H05 | HMS3678F17 | SDZ-ENA 713 | ENA 713 | perfluoro-n-octanesulfonic ac
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Rivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent. Rivastigmine hydrogen tartrate is also a dual ChEI (cholinesterase inhibitor); inhibiting BChE (butyrylcholinesterase) and AChE (acetylcholinesterase).Acetylcholinesterase and b
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Cholinesterases; ACHE & BCHE inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
A parasympathomimetic or cholinergic agent.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Phenoxy compounds
Intermediate Tree Nodes Not available
Direct Parent Phenoxy compounds
Alternative Parents Sugar acids and derivatives  Short-chain hydroxy acids and derivatives  Aralkylamines  Beta hydroxy acids and derivatives  Alpha hydroxy acids and derivatives  Monosaccharides  Fatty acids and conjugates  Dicarboxylic acids and derivatives  Carbamate esters  Trialkylamines  Secondary alcohols  1,2-diols  Organic carbonic acids and derivatives  Carboxylic acids  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organopnictogen compounds  
Molecular Framework Not available
Substituents Phenoxy compound - Beta-hydroxy acid - Aralkylamine - Sugar acid - Short-chain hydroxy acid - Alpha-hydroxy acid - Dicarboxylic acid or derivatives - Hydroxy acid - Fatty acid - Monosaccharide - Carbamic acid ester - 1,2-diol - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Carbonic acid derivative - Carboxylic acid derivative - Carboxylic acid - Hydrocarbon derivative - Organic oxide - Alcohol - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Amine - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as phenoxy compounds. These are aromatic compounds contaning a phenoxy group.
External Descriptors tartrate

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764345
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764345
IUPAC Name (2R,3R)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
INCHI InChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
InChIKey GWHQHAUAXRMMOT-MBANBULQSA-N
Smiles CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.C(C(C(=O)O)O)(C(=O)O)O
Isomeric SMILES CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
WGK Germany 3
RTECS FA9550000
PubChem CID 6918078
Molecular Weight 400.42

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
F1501131 Certificate of Analysis Jan 06, 2023 R129987
K2229795 Certificate of Analysis Dec 09, 2022 R129987
F2216222 Certificate of Analysis Jun 21, 2022 R129987
F2216221 Certificate of Analysis Jun 20, 2022 R129987
F2216220 Certificate of Analysis Jun 20, 2022 R129987

Chemical and Physical Properties

Solubility DMSO 42 mg/mL Water 80 mg/mL Ethanol 80 mg/mL
Specific Rotation[α] 5° (C=5,MeOH)
Melt Point(°C) 126 °C
Molecular Weight 400.400 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 8
Exact Mass 400.185 Da
Monoisotopic Mass 400.185 Da
Topological Polar Surface Area 148.000 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 402.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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